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10.1073/pnas.1517140113 http://scihub22266oqcxt.onion/10.1073/pnas.1517140113 C4822571!4822571 !26966232     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26966232 &cmd=llinks): Failed to open stream: HTTP request failed! 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Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets |pdf=|usr=}}{{26966232 }} gab.com Text Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26966232 #FOAvip Regulation of gene expression by transcription factors (TFs) is highly dependent on genetic background and interactions with cofactors. Identifying specific context factors is a major challenge that requires new approaches. Here we show that exploiting natural variation is a potent strategy for probing functional interactions within gene regulatory networks. We developed an algorithm to identify genetic polymorphisms that modulate the regulatory connectivity between specific transcription factors and their target genes in vivo. As a proof of principle, we mapped connectivity quantitative trait loci (cQTLs) using parallel genotype and gene expression data for segregants from a cross between two strains of the yeast Saccharomyces cerevisiae We identified a nonsynonymous mutation in the DIG2 gene as a cQTL for the transcription factor Ste12p and confirmed this prediction empirically. We also identified three polymorphisms in TAF13 as putative modulators of regulation by Gcn4p. Our method has potential for revealing how genetic differences among individuals influence gene regulatory networks in any organism for which gene expression and genotype data are available along with information on binding preferences for transcription factors. Twit Text FOAVip Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26966232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26966232 #FOAvip English Wikipedia <ref>{{Cite pmid|26966232 }}</ref> Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets #MMPMID26966232 Fazlollahi M ; Muroff I ; Lee E ; Causton HC ; Bussemaker HJ Proc Natl Acad Sci U S A 2016[Mar]; 113 (13 ): E1835-43 PMID26966232 show ga Regulation of gene expression by transcription factors (TFs) is highly dependent on genetic background and interactions with cofactors. Identifying specific context factors is a major challenge that requires new approaches. Here we show that exploiting natural variation is a potent strategy for probing functional interactions within gene regulatory networks. We developed an algorithm to identify genetic polymorphisms that modulate the regulatory connectivity between specific transcription factors and their target genes in vivo. As a proof of principle, we mapped connectivity quantitative trait loci (cQTLs) using parallel genotype and gene expression data for segregants from a cross between two strains of the yeast Saccharomyces cerevisiae We identified a nonsynonymous mutation in the DIG2 gene as a cQTL for the transcription factor Ste12p and confirmed this prediction empirically. We also identified three polymorphisms in TAF13 as putative modulators of regulation by Gcn4p. Our method has potential for revealing how genetic differences among individuals influence gene regulatory networks in any organism for which gene expression and genotype data are available along with information on binding preferences for transcription factors. |*Gene Regulatory Networks [MESH] |*Quantitative Trait Loci [MESH] |Algorithms [MESH] |Basic-Leucine Zipper Transcription Factors/genetics [MESH] |Gene Expression Regulation, Fungal [MESH] |Gene Ontology [MESH] |Genes, Mating Type, Fungal/genetics [MESH] |Models, Genetic [MESH] |Mutation [MESH] |Promoter Regions, Genetic [MESH] |Reproducibility of Results [MESH] |Saccharomyces cerevisiae Proteins/*genetics [MESH] |Saccharomyces cerevisiae/genetics [MESH]Identifying genetic modulators of the connectivity between transcripti(epmc).pdf DeepDyve Pubget Overpricing