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10.1177/1073858414568122 http://scihub22266oqcxt.onion/10.1177/1073858414568122 C4821654!4821654!25628343     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroscientist 2016 ; 22 (2): 132-44 Nephropedia Template TP {{tp|p=25628343|t=2016. 24(S)-Hydroxycholesterol as a modulator of neuronal signaling and survival |pdf=|usr=}}{{25628343}} gab.com Text 24(S)-Hydroxycholesterol as a modulator of neuronal signaling and survival JO: Neuroscientist http://www.kidney.de/pget.php?&tw=1&pmid=25628343 #FOAvip The major cholesterol metabolite in brain, 24S-hydroxycholesterol (24S-HC), serves as a vehicle for cholesterol removal. Its effects on neuronal function, however, have only recently begun to be investigated. Here we review that nascent work. Our own studies have demonstrated that 24S-HC has potent positive modulatory effects on NMDA receptor (NMDAR) function. This could have implications for brain plasticity but also for pathological NMDAR overuse. Other work has demonstrated effects of 24S-HC on neuronal survival and as a possible biomarker of neurodegenerative disease. Depending on circumstances, both upregulation/mimicry of 24S-HC signaling and downregulation/antagonism may have therapeutic potential. We are interested in the possibility that synthetic analogues of 24S-HC with positive effects at NMDARs may hold neurotherapeutic promise, given the role of NMDA receptor hypofunction in certain neuropsychiatric disorders. Twit Text FOAVip 24(S)-Hydroxycholesterol as a modulator of neuronal signaling and survival ????Neuroscientist http://www.kidney.de/pget.php?&tw=1&pmid=25628343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25628343 #FOAvip English Wikipedia <ref>{{Cite pmid|25628343}}</ref> 24(S)-Hydroxycholesterol as a modulator of neuronal signaling and survival #MMPMID25628343 Sun MY; Linsenbardt A; Emnett C; Eisenman LN; Izumi Y; Zorumski C; Mennerick S Neuroscientist 2016[Apr]; 22 (2): 132-44 PMID25628343show ga The major cholesterol metabolite in brain, 24S-hydroxycholesterol (24S-HC), serves as a vehicle for cholesterol removal. Its effects on neuronal function, however, have only recently begun to be investigated. Here we review that nascent work. Our own studies have demonstrated that 24S-HC has potent positive modulatory effects on NMDA receptor (NMDAR) function. This could have implications for brain plasticity but also for pathological NMDAR overuse. Other work has demonstrated effects of 24S-HC on neuronal survival and as a possible biomarker of neurodegenerative disease. Depending on circumstances, both upregulation/mimicry of 24S-HC signaling and downregulation/antagonism may have therapeutic potential. We are interested in the possibility that synthetic analogues of 24S-HC with positive effects at NMDARs may hold neurotherapeutic promise, given the role of NMDA receptor hypofunction in certain neuropsychiatric disorders. ä24(S)-Hydroxycholesterol as a modulator of neuronal signaling and surv(epmc).pdf DeepDyve Pubget Overpricing