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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Prog+Biophys+Mol+Biol
2016 ; 120
(1-3
): 28-36
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The Popeye domain containing protein family--A novel class of cAMP effectors with
important functions in multiple tissues
#MMPMID26772438
Schindler RF
; Brand T
Prog Biophys Mol Biol
2016[Jan]; 120
(1-3
): 28-36
PMID26772438
show ga
Popeye domain containing (Popdc) proteins are a unique family, which combine
several different properties and functions in a surprisingly complex fashion.
They are expressed in multiple tissues and cell types, present in several
subcellular compartments, interact with different classes of proteins, and are
associated with a variety of physiological and pathophysiological processes.
Moreover, Popdc proteins bind the second messenger cAMP with high affinity and it
is thought that they act as a novel class of cAMP effector proteins. Here, we
will review the most important findings about the Popdc family, which accumulated
since its discovery about 15 years ago. We will be focussing on Popdc protein
interaction and function in striated muscle tissue. However, as a full picture
only emerges if all aspects are taken into account, we will also describe what is
currently known about the role of Popdc proteins in epithelial cells and in
various types of cancer, and discuss these findings with regard to their
relevance for cardiac and skeletal muscle.