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10.1165/rcmb.2015-0145OC http://scihub22266oqcxt.onion/10.1165/rcmb.2015-0145OC C4821053!4821053!26414702     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Cell+Mol+Biol 2016 ; 54 (4): 574-83 Nephropedia Template TP {{tp|p=26414702|t=2016. Altered Hypoxic?Adenosine Axis and Metabolism in Group III Pulmonary Hypertension |pdf=|usr=}}{{26414702}} gab.com Text Altered Hypoxic Adenosine Axis and Metabolism in Group III Pulmonary Hypertension JO: Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26414702 #FOAvip Group III pulmonary hypertension (PH) is a highly prevalent and deadly lung disorder with limited treatment options other than transplantation. Group III PH affects patients with ongoing chronic lung injury, such as idiopathic pulmonary fibrosis (IPF). Between 30 and 40% of patients with IPF are diagnosed with PH. The diagnosis of PH has devastating consequences to these patients, leading to increased morbidity and mortality, yet the molecular mechanisms involved in the development of PH in patients with chronic lung disease remain elusive. Our hypothesis was that the hypoxic?adenosinergic system is enhanced in patients with group III PH compared with patients with IPF with no PH. Explanted lung tissue was analyzed for markers of the hypoxic?adenosine axis, including expression levels of hypoxia-inducible factor (HIF)-1A, adenosine A2B receptor, CD73, and equilibrative nucleotide transporter-1. In addition, we assessed whether altered mitochondrial metabolism was present in these samples. Increased expression of HIF-1A was observed in tissues from patients with group III PH. These changes were consistent with increased evidence of adenosine accumulation in group III PH. A novel observation of our study was of evidence suggesting altered mitochondrial metabolism in lung tissue from group III PH leading to increased succinate levels that are able to further stabilize HIF-1A. Our data demonstrate that the hypoxic?adenosine axis is up-regulated in group III PH and that subsequent succinate accumulation may play a part in the development of group III PH. Twit Text FOAVip Altered Hypoxic Adenosine Axis and Metabolism in Group III Pulmonary Hypertension ????Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26414702 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26414702 #FOAvip English Wikipedia <ref>{{Cite pmid|26414702}}</ref> Altered Hypoxic?Adenosine Axis and Metabolism in Group III Pulmonary Hypertension #MMPMID26414702 Garcia-Morales LJ; Chen NY; Weng T; Luo F; Davies J; Philip K; Volcik KA; Melicoff E; Amione-Guerra J; Bunge RR; Bruckner BA; Loebe M; Eltzschig HK; Pandit LM; Blackburn MR; Karmouty-Quintana H Am J Respir Cell Mol Biol 2016[Apr]; 54 (4): 574-83 PMID26414702show ga Group III pulmonary hypertension (PH) is a highly prevalent and deadly lung disorder with limited treatment options other than transplantation. Group III PH affects patients with ongoing chronic lung injury, such as idiopathic pulmonary fibrosis (IPF). Between 30 and 40% of patients with IPF are diagnosed with PH. The diagnosis of PH has devastating consequences to these patients, leading to increased morbidity and mortality, yet the molecular mechanisms involved in the development of PH in patients with chronic lung disease remain elusive. Our hypothesis was that the hypoxic?adenosinergic system is enhanced in patients with group III PH compared with patients with IPF with no PH. Explanted lung tissue was analyzed for markers of the hypoxic?adenosine axis, including expression levels of hypoxia-inducible factor (HIF)-1A, adenosine A2B receptor, CD73, and equilibrative nucleotide transporter-1. In addition, we assessed whether altered mitochondrial metabolism was present in these samples. Increased expression of HIF-1A was observed in tissues from patients with group III PH. These changes were consistent with increased evidence of adenosine accumulation in group III PH. A novel observation of our study was of evidence suggesting altered mitochondrial metabolism in lung tissue from group III PH leading to increased succinate levels that are able to further stabilize HIF-1A. Our data demonstrate that the hypoxic?adenosine axis is up-regulated in group III PH and that subsequent succinate accumulation may play a part in the development of group III PH. äAltered Hypoxic?Adenosine Axis and Metabolism in Group III Pulmonary H(epmc).pdf DeepDyve Pubget Overpricing