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10.1177/0271678X15606148 http://scihub22266oqcxt.onion/10.1177/0271678X15606148 C4821018!4821018 !26661156     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26661156 &cmd=llinks): Failed to open stream: HTTP request failed! 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CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation |pdf=|usr=}}{{26661156 }} gab.com Text CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26661156 #FOAvip There are numerous barriers to white matter repair after central nervous system injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter attack oligodendrocyte precursor cells via toll-like receptor 4 signaling thus interfering with this endogenous progenitor recovery mechanism. Primary cell culture experiments demonstrate that peritoneal macrophages can attack and digest oligodendrocyte precursor cells via toll-like receptor 4 signaling, and this phagocytosis of oligodendrocyte precursor cells can be inhibited by using CD200-Fc to downregulate toll-like receptor 4. In an in vivo model of white matter ischemia induced by endothelin-1, treatment with CD200-Fc suppressed toll-like receptor 4 expression in peripherally circulating macrophages, thus restraining macrophage phagocytosis of oligodendrocyte precursor cells and leading to improved myelination. Taken together, these findings suggest that deleterious macrophage effects may occur after white matter ischemia, whereby macrophages attack oligodendrocyte precursor cells and interfere with endogenous recovery responses. Targeting this pathway with CD200 may offer a novel therapeutic approach to amplify endogenous oligodendrocyte precursor cell-mediated repair of white matter damage in mammalian brain. Twit Text FOAVip CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26661156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26661156 #FOAvip English Wikipedia <ref>{{Cite pmid|26661156 }}</ref> CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation #MMPMID26661156 Hayakawa K ; Pham LD ; Seo JH ; Miyamoto N ; Maki T ; Terasaki Y ; Sakad?i? S ; Boas D ; van Leyen K ; Waeber C ; Kim KW ; Arai K ; Lo EH J Cereb Blood Flow Metab 2016[Apr]; 36 (4 ): 781-93 PMID26661156 show ga There are numerous barriers to white matter repair after central nervous system injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter attack oligodendrocyte precursor cells via toll-like receptor 4 signaling thus interfering with this endogenous progenitor recovery mechanism. Primary cell culture experiments demonstrate that peritoneal macrophages can attack and digest oligodendrocyte precursor cells via toll-like receptor 4 signaling, and this phagocytosis of oligodendrocyte precursor cells can be inhibited by using CD200-Fc to downregulate toll-like receptor 4. In an in vivo model of white matter ischemia induced by endothelin-1, treatment with CD200-Fc suppressed toll-like receptor 4 expression in peripherally circulating macrophages, thus restraining macrophage phagocytosis of oligodendrocyte precursor cells and leading to improved myelination. Taken together, these findings suggest that deleterious macrophage effects may occur after white matter ischemia, whereby macrophages attack oligodendrocyte precursor cells and interfere with endogenous recovery responses. Targeting this pathway with CD200 may offer a novel therapeutic approach to amplify endogenous oligodendrocyte precursor cell-mediated repair of white matter damage in mammalian brain. |Animals [MESH] |Antigens, CD/*pharmacology [MESH] |Brain Ischemia/pathology [MESH] |Down-Regulation/drug effects [MESH] |L-Lactate Dehydrogenase/metabolism [MESH] |Macrophages/*drug effects [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myelin Sheath/metabolism [MESH] |Neural Stem Cells/*drug effects [MESH] |Oligodendroglia/*drug effects [MESH] |Phagocytosis/drug effects [MESH] |Toll-Like Receptor 4/*biosynthesis/genetics [MESH]CD200 restrains macrophage attack on oligodendrocyte precursors via to(epmc).pdf DeepDyve Pubget Overpricing