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Correlates of sexual activity and sexually transmitted infections among human
immunodeficiency virus-infected youth in the LEGACY cohort, United States, 2006
#MMPMID22001904
Setse RW
; Siberry GK
; Gravitt PE
; Moss WJ
; Agwu AL
; Wheeling JT
; Bohannon BA
; Dominguez KL
Pediatr Infect Dis J
2011[Nov]; 30
(11
): 967-73
PMID22001904
show ga
BACKGROUND: To determine the prevalence and correlates of sexual activity and
sexually transmitted infections (STIs) among human immunodeficiency virus
(HIV)-infected youth. METHODS: The Longitudinal Epidemiologic Study to Gain
Insight into HIV/AIDS in Children and Youth (LEGACY) is an observational medical
record study of perinatally and behaviorally HIV-infected (PHIV and BHIV) youth
followed at 22 US HIV clinics. PHIV youth were HIV infected at birth or by
breast-feeding. BHIV youth were HIV infected sexually or by injection drug use.
We determined the prevalence of sexual activity during 2006 and examined
correlates of sexual activity among 13- to 24-year-old PHIV youth using
multivariable generalized linear models. Among sexually active persons, we
determined the association between mode of HIV acquisition and non-HIV STI
diagnosis using multivariable generalized linear models. RESULTS: In all, 34%
(195/571) of PHIV and 89% (162/181) of BHIV youth were sexually active. Eighty
percent (155/195) of sexually active PHIV youth reported ever using condoms.
Ninety-three percent discussed sex with a health care provider. Increasing age
(adjusted prevalence ratio [APR]: 1.17 per year of age, 95% confidence interval
[CI] = 1.12-1.23), having a boyfriend/girlfriend (APR: 2.74, 95% CI = 1.75-4.29),
and injection drug use (APR: 1.38, 95% CI = 1.06-1.79) correlated with sexual
activity after adjusting for socio-demographic and HIV-related clinical
variables. Among sexually active youth, after adjusting for relevant confounders,
PHIV youth were less likely than BHIV youth to have been diagnosed with an STI in
2006 (APR: 0.25, 95% CI = 0.13-0.46). CONCLUSIONS: Sexual activity among
HIV-infected adolescents is common. Factors associated with sexual activity in
this study should be taken into account in developing behavioral risk reduction
interventions targeting PHIV youth.
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