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10.1038/ncomms11097 http://scihub22266oqcxt.onion/10.1038/ncomms11097 C4820538!4820538 !27020697     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27020697 &cmd=llinks): Failed to open stream: HTTP request failed! 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Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture |pdf=|usr=}}{{27020697 }} gab.com Text Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27020697 #FOAvip Mg(2+) plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg(2+)]i in megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is a ubiquitous, constitutively active cation channel with a cytosolic ?-kinase domain that is critical for embryonic development and cell survival. Here we report that impaired channel function of TRPM7 in MKs causes macrothrombocytopenia in mice (Trpm7(fl/fl-Pf4Cre)) and likely in several members of a human pedigree that, in addition, suffer from atrial fibrillation. The defect in platelet biogenesis is mainly caused by cytoskeletal alterations resulting in impaired proplatelet formation by Trpm7(fl/fl-Pf4Cre) MKs, which is rescued by Mg(2+) supplementation or chemical inhibition of non-muscle myosin IIA heavy chain activity. Collectively, our findings reveal that TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice. Twit Text FOAVip Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27020697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27020697 #FOAvip English Wikipedia <ref>{{Cite pmid|27020697 }}</ref> Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture #MMPMID27020697 Stritt S ; Nurden P ; Favier R ; Favier M ; Ferioli S ; Gotru SK ; van Eeuwijk JM ; Schulze H ; Nurden AT ; Lambert MP ; Turro E ; Burger-Stritt S ; Matsushita M ; Mittermeier L ; Ballerini P ; Zierler S ; Laffan MA ; Chubanov V ; Gudermann T ; Nieswandt B ; Braun A Nat Commun 2016[Mar]; 7 (ä): 11097 PMID27020697 show ga Mg(2+) plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg(2+)]i in megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is a ubiquitous, constitutively active cation channel with a cytosolic ?-kinase domain that is critical for embryonic development and cell survival. Here we report that impaired channel function of TRPM7 in MKs causes macrothrombocytopenia in mice (Trpm7(fl/fl-Pf4Cre)) and likely in several members of a human pedigree that, in addition, suffer from atrial fibrillation. The defect in platelet biogenesis is mainly caused by cytoskeletal alterations resulting in impaired proplatelet formation by Trpm7(fl/fl-Pf4Cre) MKs, which is rescued by Mg(2+) supplementation or chemical inhibition of non-muscle myosin IIA heavy chain activity. Collectively, our findings reveal that TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice. |*Homeostasis [MESH] |*Thrombopoiesis [MESH] |Animals [MESH] |Blood Platelets/metabolism [MESH] |Cytoskeleton/*metabolism [MESH] |Humans [MESH] |Magnesium/*metabolism [MESH] |Megakaryocytes/metabolism [MESH] |Mice [MESH] |Mutant Proteins/metabolism [MESH] |Nonmuscle Myosin Type IIA/metabolism [MESH] |Protein Serine-Threonine Kinases/deficiency/*metabolism [MESH] |TRPM Cation Channels/deficiency/*metabolism [MESH]Defects in TRPM7 channel function deregulate thrombopoiesis through al(epmc).pdf DeepDyve Pubget Overpricing