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10.4049/jimmunol.1402681 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402681 C4820392!4820392 !26800872     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26800872 &cmd=llinks): Failed to open stream: HTTP request failed! 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C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils |pdf=|usr=}}{{26800872 }} gab.com Text C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF- B Activation in Neutrophils JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26800872 #FOAvip Recently, ceramide-1-phosphate (C1P) has been shown to modulate acute inflammatory events. Acute lung injury (Arnalich et al. 2000. Infect. Immun. 68: 1942-1945) is characterized by rapid alveolar injury, lung inflammation, induced cytokine production, neutrophil accumulation, and vascular leakage leading to lung edema. The aim of this study was to investigate the role of C1P during LPS-induced acute lung injury in mice. To evaluate the effect of C1P, we used a prophylactic and therapeutic LPS-induced ALI model in C57BL/6 male mice. Our studies revealed that intrapulmonary application of C1P before (prophylactic) or 24 h after (therapeutic) LPS instillation decreased neutrophil trafficking to the lung, proinflammatory cytokine levels in bronchoalveolar lavage, and alveolar capillary leakage. Mechanistically, C1P inhibited the LPS-triggered NF-?B levels in lung tissue in vivo. In addition, ex vivo experiments revealed that C1P also attenuates LPS-induced NF-?B phosphorylation and IL-8 production in human neutrophils. These results indicate C1P playing a role in dampening LPS-induced acute lung inflammation and suggest that C1P could be a valuable candidate for treatment of ALI. Twit Text FOAVip C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF- B Activation in Neutrophils ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26800872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26800872 #FOAvip English Wikipedia <ref>{{Cite pmid|26800872 }}</ref> C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils #MMPMID26800872 Baudiß K ; de Paula Vieira R ; Cicko S ; Ayata K ; Hossfeld M ; Ehrat N ; Gómez-Muñoz A ; Eltzschig HK ; Idzko M J Immunol 2016[Mar]; 196 (5 ): 2319-26 PMID26800872 show ga Recently, ceramide-1-phosphate (C1P) has been shown to modulate acute inflammatory events. Acute lung injury (Arnalich et al. 2000. Infect. Immun. 68: 1942-1945) is characterized by rapid alveolar injury, lung inflammation, induced cytokine production, neutrophil accumulation, and vascular leakage leading to lung edema. The aim of this study was to investigate the role of C1P during LPS-induced acute lung injury in mice. To evaluate the effect of C1P, we used a prophylactic and therapeutic LPS-induced ALI model in C57BL/6 male mice. Our studies revealed that intrapulmonary application of C1P before (prophylactic) or 24 h after (therapeutic) LPS instillation decreased neutrophil trafficking to the lung, proinflammatory cytokine levels in bronchoalveolar lavage, and alveolar capillary leakage. Mechanistically, C1P inhibited the LPS-triggered NF-?B levels in lung tissue in vivo. In addition, ex vivo experiments revealed that C1P also attenuates LPS-induced NF-?B phosphorylation and IL-8 production in human neutrophils. These results indicate C1P playing a role in dampening LPS-induced acute lung inflammation and suggest that C1P could be a valuable candidate for treatment of ALI. |Acute Lung Injury/drug therapy/*etiology/*metabolism/pathology [MESH] |Animals [MESH] |Ceramides/*metabolism/pharmacology [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Humans [MESH] |Interleukin-8/metabolism [MESH] |Lipopolysaccharides/*adverse effects [MESH] |Male [MESH] |Mice [MESH] |NF-kappa B/genetics/*metabolism [MESH] |Neutrophils/drug effects/*immunology/*metabolism [MESH] |Phosphorylation [MESH]C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Prevent(epmc).pdf DeepDyve Pubget Overpricing