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10.1038/npp.2015.315 http://scihub22266oqcxt.onion/10.1038/npp.2015.315 C4820039!4820039 !26462618     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26462618 &cmd=llinks): Failed to open stream: HTTP request failed! 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How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear |pdf=|usr=}}{{26462618 }} gab.com Text How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear JO: Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26462618 #FOAvip Combining beta-blockers with exposure therapy has been advocated to reduce fear, yet experimental studies combining beta-blockers with memory reactivation have had contradictory results. We explored how beta-blockade might affect the course of safety learning and the subsequent return of fear in a double-blind placebo-controlled functional magnetic resonance imaging study in humans (N=46). A single dose of propranolol before extinction learning caused a loss of conditioned fear responses, and prevented the subsequent return of fear and decreased explicit memory for the fearful events in the absence of drug. Fear-related neural responses were persistently attenuated in the dorsal medial prefrontal cortex (dmPFC), increased in the hippocampus 24?h later, and correlated with individual behavioral indices of fear. Prediction error-related responses in the ventral striatum persisted during beta-blockade. We suggest that this pattern of results is most consistent with a model where beta-blockade can prevent the return of fear by (i) reducing retrieval of fear memory, via the dmPFC and (ii) increasing contextual safety learning, via the hippocampus. Our findings suggest that retrieval of fear memory and contextual safety learning form potential mnemonic target mechanisms to optimize exposure-based therapy with beta-blockers. Twit Text FOAVip How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear ????Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26462618 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26462618 #FOAvip English Wikipedia <ref>{{Cite pmid|26462618 }}</ref> How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear #MMPMID26462618 Kroes MC ; Tona KD ; den Ouden HE ; Vogel S ; van Wingen GA ; Fernández G Neuropsychopharmacology 2016[May]; 41 (6 ): 1569-78 PMID26462618 show ga Combining beta-blockers with exposure therapy has been advocated to reduce fear, yet experimental studies combining beta-blockers with memory reactivation have had contradictory results. We explored how beta-blockade might affect the course of safety learning and the subsequent return of fear in a double-blind placebo-controlled functional magnetic resonance imaging study in humans (N=46). A single dose of propranolol before extinction learning caused a loss of conditioned fear responses, and prevented the subsequent return of fear and decreased explicit memory for the fearful events in the absence of drug. Fear-related neural responses were persistently attenuated in the dorsal medial prefrontal cortex (dmPFC), increased in the hippocampus 24?h later, and correlated with individual behavioral indices of fear. Prediction error-related responses in the ventral striatum persisted during beta-blockade. We suggest that this pattern of results is most consistent with a model where beta-blockade can prevent the return of fear by (i) reducing retrieval of fear memory, via the dmPFC and (ii) increasing contextual safety learning, via the hippocampus. Our findings suggest that retrieval of fear memory and contextual safety learning form potential mnemonic target mechanisms to optimize exposure-based therapy with beta-blockers. |Adrenergic beta-Antagonists/*pharmacology [MESH] |Brain/diagnostic imaging/drug effects/physiology [MESH] |Double-Blind Method [MESH] |Extinction, Psychological/*drug effects [MESH] |Fear/*drug effects [MESH] |Female [MESH] |Functional Neuroimaging [MESH] |Hippocampus/diagnostic imaging/drug effects/physiology [MESH] |Humans [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Memory/drug effects [MESH] |Prefrontal Cortex/diagnostic imaging/drug effects/physiology [MESH]How Administration of the Beta-Blocker Propranolol Before Extinction c(epmc).pdf DeepDyve Pubget Overpricing