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2016 ; 10
(3
): 363-71
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Asthma and chronic obstructive pulmonary disease overlap syndrome (ACOS):
structured literature review and physician insights
#MMPMID26789845
Ding B
; Enstone A
Expert Rev Respir Med
2016[]; 10
(3
): 363-71
PMID26789845
show ga
OBJECTIVES: To understand the key characteristics of Asthma and Chronic
Obstructive Pulmonary Disease Overlap Syndrome (ACOS) and to identify evidence
gaps relating to the identification, treatment and management of ACOS patients.
METHODS: A structured literature review and 1-hour telephone interviews with
specialist respiratory physicians were conducted (n=10; China, France, Germany,
Japan and the USA). RESULTS: All 10 physicians used the term ACOS in clinical
practice. ACOS was not clearly defined in the literature. Prevalence of ACOS
among adult patients with COPD or asthma ranged from 12-55%. ACOS patients had
severe disease, with increased exacerbations and hospitalisations compared to
some asthma and COPD patients. ACOS represented a clinical challenge due to a
lack of evidence-based guidelines distinguishing between asthma, COPD and ACOS.
Published data quantifying ACOS costs were limited. CONCLUSIONS: There is a need
for consensus evidence-based guidance to facilitate earlier diagnosis and to
optimise the management of ACOS patients.