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10.3109/10409238.2015.1117053 http://scihub22266oqcxt.onion/10.3109/10409238.2015.1117053 C4819810!4819810 !26627871     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26627871 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Rev+Biochem+Mol+Biol 2016 ; 51 (2 ): 74-85 Nephropedia Template TP {{tp|p=26627871 |t=2016. Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells |pdf=|usr=}}{{26627871 }} gab.com Text Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26627871 #FOAvip Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essential genes has been tightly linked to the development and deployment of various screening technologies. Here, we describe how gene essentiality was addressed in different eukaryotic model organisms, covering a range of organisms from yeast to mouse. We describe how increasing knowledge of evolutionarily divergent genomes facilitate identification of gene essentiality across species. Finally, the impact of gene essentiality and synthetic lethality on cancer research and the clinical translation of screening results are highlighted. Twit Text FOAVip Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26627871 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26627871 #FOAvip English Wikipedia <ref>{{Cite pmid|26627871 }}</ref> Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells #MMPMID26627871 Zhan T ; Boutros M Crit Rev Biochem Mol Biol 2016[]; 51 (2 ): 74-85 PMID26627871 show ga Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essential genes has been tightly linked to the development and deployment of various screening technologies. Here, we describe how gene essentiality was addressed in different eukaryotic model organisms, covering a range of organisms from yeast to mouse. We describe how increasing knowledge of evolutionarily divergent genomes facilitate identification of gene essentiality across species. Finally, the impact of gene essentiality and synthetic lethality on cancer research and the clinical translation of screening results are highlighted. |*Genes, Essential [MESH] |*Models, Biological [MESH] |Animals [MESH] |Computational Biology [MESH] |Humans [MESH]Towards a compendium of essential genes - From model organisms to synt(epmc).pdf DeepDyve Pubget Overpricing