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10.3109/14397595.2014.881709 http://scihub22266oqcxt.onion/10.3109/14397595.2014.881709 C4819587!4819587 !24593170     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24593170 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study |pdf=|usr=}}{{24593170 }} gab.com Text Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study JO: Mod Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24593170 #FOAvip OBJECTIVES: To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS: J-RAPID double-blind patients were entered into an open-label extension (OLE) study. Patients withdrawn due to lack of efficacy at 16 weeks and double-blind completers without a week-24 American College of Rheumatology (ACR) 20 response received CZP 200 mg every other week (Q2W) plus methotrexate. Double-blind completers with week-24 ACR20 responses were randomized to CZP 200 mg Q2W plus methotrexate or CZP 400 mg every 4 weeks plus methotrexate. RESULTS: The ACR20/ACR50/ACR70 response rates of double-blind completers (n = 204) were 89.7%/67.2%/36.3% at OLE entry and 95.6%/84.8%/58.3% at 52 weeks, respectively. Other clinical, functional and radiographic outcomes were sustained with long-term CZP plus methotrexate. Long-term treatment with CZP was well-tolerated with no new unexpected adverse events observed. The efficacy and safety of CZP treatment were similar between the two dosing schedules. CONCLUSIONS: Continued CZP administration with methotrexate maintained efficacy over 52 weeks and was well-tolerated for Japanese RA patients. No obvious differences in clinical efficacy and safety were observed between the two dosing schedules, giving flexibility in maintenance administration schedules. Twit Text FOAVip Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study ????Mod Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24593170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24593170 #FOAvip English Wikipedia <ref>{{Cite pmid|24593170 }}</ref> Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study #MMPMID24593170 Tanaka Y ; Yamamoto K ; Takeuchi T ; Yamanaka H ; Ishiguro N ; Eguchi K ; Watanabe A ; Origasa H ; Shoji T ; Miyasaka N ; Koike T Mod Rheumatol 2014[Sep]; 24 (5 ): 734-43 PMID24593170 show ga OBJECTIVES: To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS: J-RAPID double-blind patients were entered into an open-label extension (OLE) study. Patients withdrawn due to lack of efficacy at 16 weeks and double-blind completers without a week-24 American College of Rheumatology (ACR) 20 response received CZP 200 mg every other week (Q2W) plus methotrexate. Double-blind completers with week-24 ACR20 responses were randomized to CZP 200 mg Q2W plus methotrexate or CZP 400 mg every 4 weeks plus methotrexate. RESULTS: The ACR20/ACR50/ACR70 response rates of double-blind completers (n = 204) were 89.7%/67.2%/36.3% at OLE entry and 95.6%/84.8%/58.3% at 52 weeks, respectively. Other clinical, functional and radiographic outcomes were sustained with long-term CZP plus methotrexate. Long-term treatment with CZP was well-tolerated with no new unexpected adverse events observed. The efficacy and safety of CZP treatment were similar between the two dosing schedules. CONCLUSIONS: Continued CZP administration with methotrexate maintained efficacy over 52 weeks and was well-tolerated for Japanese RA patients. No obvious differences in clinical efficacy and safety were observed between the two dosing schedules, giving flexibility in maintenance administration schedules. |Adult [MESH] |Aged [MESH] |Antibodies, Monoclonal, Humanized/adverse effects/*therapeutic use [MESH] |Antirheumatic Agents/adverse effects/*therapeutic use [MESH] |Arthritis, Rheumatoid/diagnostic imaging/*drug therapy [MESH] |Arthrography [MESH] |Certolizumab Pegol [MESH] |Disease Progression [MESH] |Double-Blind Method [MESH] |Drug Administration Schedule [MESH] |Female [MESH] |Humans [MESH] |Immunoglobulin Fab Fragments/adverse effects/*therapeutic use [MESH] |Japan [MESH] |Male [MESH] |Methotrexate/adverse effects/*therapeutic use [MESH] |Middle Aged [MESH] |Polyethylene Glycols/adverse effects/*therapeutic use [MESH] |Quality of Life [MESH] |Retreatment [MESH]Long-term efficacy and safety of certolizumab pegol in Japanese rheuma(epmc).pdf DeepDyve Pubget Overpricing