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10.15252/embj.201693946

http://scihub22266oqcxt.onion/10.15252/embj.201693946
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C4818767!4818767!26896443
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suck abstract from ncbi


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pmid26896443      EMBO+J 2016 ; 35 (7): 699-700
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  • Starting too soon: upstream reading frames repress downstream translation #MMPMID26896443
  • McGeachy AM; Ingolia NT
  • EMBO J 2016[Apr]; 35 (7): 699-700 PMID26896443show ga
  • Upstream open reading frames (uORFs) are known to regulate a few specific transcripts, and recent computational and experimental studies have suggested candidate uORF regulation across the genome. In this issue, Johnstone et al (2016) use ribosome profiling to identify translated uORFs and measure their effects on downstream translation. Furthermore, they show that regulatory uORFs are conserved across species and subject to selective constraint. Recognizing the potential of uORFs in regulating translation expands our understanding of the dynamic regulation of gene expression.
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