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10.1042/CS20150087 http://scihub22266oqcxt.onion/10.1042/CS20150087 C4818578!4818578!26814203     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2016 ; 130 (5): 317-35 Nephropedia Template TP {{tp|p=26814203|t=2016. NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?|pdf=|usr=}}{{26814203}} gab.com Text NADPH oxidases: key modulators in aging and age-related cardiovascular diseases JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=26814203 #FOAvip Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of ?longevity genes? and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. Twit Text FOAVip NADPH oxidases: key modulators in aging and age-related cardiovascular diseases ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=26814203 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26814203 #FOAvip English Wikipedia <ref>{{Cite pmid|26814203}}</ref> NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? #MMPMID26814203 Sahoo S; Meijles DN; Pagano PJ Clin Sci (Lond) 2016[Mar]; 130 (5): 317-35 PMID26814203show ga Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of ?longevity genes? and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. äNADPH oxidases: key modulators in aging and age-related cardiovascular(epmc).pdf DeepDyve Pubget Overpricing