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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Health+Qual+Life+Outcomes
2016 ; 14
(ä): 54
Nephropedia Template TP
gab.com Text
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English Wikipedia
Relationship between pain relief, reduction in pain-associated sleep
interference, and overall impression of improvement in patients with postherpetic
neuralgia treated with extended-release gabapentin
#MMPMID27037091
Mehta N
; Bucior I
; Bujanover S
; Shah R
; Gulati A
Health Qual Life Outcomes
2016[Apr]; 14
(ä): 54
PMID27037091
show ga
BACKGROUND: Postherpetic neuralgia (PHN) interferes with patients' quality of
life, and disturbed sleep is a prevalent complaint. Pain-associated sleep
interference in turn enhances pain and/or reduces pain tolerance. Therefore,
reducing sleep interference by pain, in addition to pain control, may improve
patient care. To address this notion, we characterized relationships among
changes in pain intensity, sleep interference, and overall impression of
improvement in PHN patients treated with gastroretentive gabapentin (G-GR).
METHODS: Patients with PHN (n?=?556) received G-GR 1,800 mg once-daily in two
phase 3 and one phase 4 study. Visual Analog Scale (VAS) and Brief Pain Inventory
(BPI) were completed at baseline and the end of study. Patients' Global
Impression of Change (PGIC) was completed at the end of study. Regression
analyses examined relationships between VAS, BPI sleep interference by pain, and
PGIC. RESULTS: At the end of treatment, 53.7 and 63.2 % of patients reported a ?
30 % reduction in VAS and BPI pain-associated sleep interference (BPISI)
respectively; 46.3 % reported feeling "Much" or "Very Much" improved on the PGIC.
There were positive correlations between the percent reductions in VAS and BPISI;
both correlated with PGIC improvements. Percent changes in VAS and BPISI were
significant (p?0.0001 and p?=?0.0082, respectively), and were independent
predictors of feeling "Much" or "Very Much" improved on the PGIC. CONCLUSIONS:
Reductions in pain intensity and in BPISI were correlated, and both also
correlated with overall impression of improvement for patients with PHN treated
with G-GR. Both pain relief and improvement BPISI independently predicted
improvement in PGIC. For optimal patient care, clinicians should consider
reducing the impact of pain on quality of sleep as well as overall pain
reduction. TRIAL REGISTRATION: ClinicalTrials.gov numbers, NCT00335933 ,
NCT00636636 , NCT01426230.
|*Quality of Life
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Amines/*therapeutic use
[MESH]
|Analgesics/*therapeutic use
[MESH]
|Cyclohexanecarboxylic Acids/*therapeutic use
[MESH]
|Delayed-Action Preparations/therapeutic use
[MESH]