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10.1186/s12955-016-0456-0

http://scihub22266oqcxt.onion/10.1186/s12955-016-0456-0
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C4818513!4818513 !27037091
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suck abstract from ncbi


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pmid27037091
      Health+Qual+Life+Outcomes 2016 ; 14 (ä): 54
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  • Relationship between pain relief, reduction in pain-associated sleep interference, and overall impression of improvement in patients with postherpetic neuralgia treated with extended-release gabapentin #MMPMID27037091
  • Mehta N ; Bucior I ; Bujanover S ; Shah R ; Gulati A
  • Health Qual Life Outcomes 2016[Apr]; 14 (ä): 54 PMID27037091 show ga
  • BACKGROUND: Postherpetic neuralgia (PHN) interferes with patients' quality of life, and disturbed sleep is a prevalent complaint. Pain-associated sleep interference in turn enhances pain and/or reduces pain tolerance. Therefore, reducing sleep interference by pain, in addition to pain control, may improve patient care. To address this notion, we characterized relationships among changes in pain intensity, sleep interference, and overall impression of improvement in PHN patients treated with gastroretentive gabapentin (G-GR). METHODS: Patients with PHN (n?=?556) received G-GR 1,800 mg once-daily in two phase 3 and one phase 4 study. Visual Analog Scale (VAS) and Brief Pain Inventory (BPI) were completed at baseline and the end of study. Patients' Global Impression of Change (PGIC) was completed at the end of study. Regression analyses examined relationships between VAS, BPI sleep interference by pain, and PGIC. RESULTS: At the end of treatment, 53.7 and 63.2 % of patients reported a ? 30 % reduction in VAS and BPI pain-associated sleep interference (BPISI) respectively; 46.3 % reported feeling "Much" or "Very Much" improved on the PGIC. There were positive correlations between the percent reductions in VAS and BPISI; both correlated with PGIC improvements. Percent changes in VAS and BPISI were significant (p?
  • |*Quality of Life [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Amines/*therapeutic use [MESH]
  • |Analgesics/*therapeutic use [MESH]
  • |Cyclohexanecarboxylic Acids/*therapeutic use [MESH]
  • |Delayed-Action Preparations/therapeutic use [MESH]
  • |Female [MESH]
  • |Gabapentin [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Neuralgia, Postherpetic/*drug therapy [MESH]
  • |Pain Management [MESH]
  • |Pain Measurement/*drug effects [MESH]
  • |Prevalence [MESH]
  • |Sleep/*drug effects [MESH]
  • |Treatment Outcome [MESH]
  • |Young Adult [MESH]


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