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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Dev+Behav+Pediatr
2016 ; 37
(3
): 231-8
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gab.com Text
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English Wikipedia
Neurocognitive, Social-Behavioral, and Adaptive Functioning in Preschool Children
with Mild to Moderate Kidney Disease
#MMPMID26890559
Hooper SR
; Gerson AC
; Johnson RJ
; Mendley SR
; Shinnar S
; Lande MB
; Matheson MB
; Gipson DS
; Morgenstern B
; Warady BA
; Furth SL
J Dev Behav Pediatr
2016[Apr]; 37
(3
): 231-8
PMID26890559
show ga
OBJECTIVE: The negative impact of end-stage kidney disease on cognitive function
in children is well established, but no studies have examined the neurocognitive,
social-behavioral, and adaptive behavior skills of preschool children with mild
to moderate chronic kidney disease (CKD). METHOD: Participants included 124
preschool children with mild to moderate CKD, aged 12 to 68 months (median = 3.7
years), and an associated mean glomerular filtration rate (GFR) of 50.0
mLˇminˇ1.73 m. In addition to level of function and percent of participants
scoring ?1 SD below the test mean, regression models examined the associations
between biomarkers of CKD (GFR, anemia, hypertension, seizures, and abnormal
birth history), and developmental level/IQ, attention regulation, and parent
ratings of executive functions, social-behavior, and adaptive behaviors. RESULTS:
Median scores for all measures were in the average range; however, 27% were
deemed at risk for a developmental level/IQ <85, 20% were at-risk for attention
variability, and parent ratings indicated 30% and 37% to be at risk for executive
dysfunction and adaptive behavior problems, respectively. Approximately 43% were
deemed at risk on 2 or more measures. None of the disease-related variables were
significantly associated with these outcomes, although the presence of
hypertension approached significance for attention variability (p < .09).
Abnormal birth history and lower maternal education were significantly related to
lower developmental level/IQ; seizures were related to lower parental ratings of
executive function and adaptive behavior; and abnormal birth history was
significantly related to lower ratings of adaptive behavior. When predicting risk
status, the logistic regression did evidence both higher GFR and the lack of
anemia to be associated with more intact developmental level/IQ. CONCLUSION:
These findings suggest relatively intact functioning for preschool children with
mild to moderate CKD, but the need for ongoing developmental surveillance in this
population remains warranted, particularly for those with abnormal birth
histories, seizures, and heightened disease severity.