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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 AIDS+Res+Hum+Retroviruses 2016 ; 32 (4): 386-9 Nephropedia Template TP
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Short Communication: HIV-1 Infection Suppresses Circulating Viral Restriction microRNAs #MMPMID26607272
Zhou Y; Sun L; Wang X; Liang H; Ye L; Zhou L; Liang BY; Li JL; Liu MQ; Peng JS; Zhou DJ; Gui XE; Ho WZ
AIDS Res Hum Retroviruses 2016[Apr]; 32 (4): 386-9 PMID26607272show ga
MicroRNAs (miRNAs) participate in host innate immunity against HIV-1 infection. We examined the impact of HIV-1 infection on viral restriction miRNAs in plasma of HIV-1?infected subjects. HIV-1?infected subjects had significantly lower plasma levels of HIV-1 restriction miRNAs (miRs-29a, ?29b, ?125b, ?223, ?198, and ?382) than control subjects. Further in vitro studies showed that HIV-1 infection of macrophages suppressed production of the extracellular miRs-29b, ?125b, and ?223. These data demonstrate the compelling evidence that HIV-1 infection impairs host innate immunity by inhibiting antiviral miRNAs, which provide a possible mechanism for HIV-1 persistence in the host.