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10.1089/aid.2015.0253

http://scihub22266oqcxt.onion/10.1089/aid.2015.0253
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C4817567!4817567!26607272
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suck abstract from ncbi


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pmid26607272      AIDS+Res+Hum+Retroviruses 2016 ; 32 (4): 386-9
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  • Short Communication: HIV-1 Infection Suppresses Circulating Viral Restriction microRNAs #MMPMID26607272
  • Zhou Y; Sun L; Wang X; Liang H; Ye L; Zhou L; Liang BY; Li JL; Liu MQ; Peng JS; Zhou DJ; Gui XE; Ho WZ
  • AIDS Res Hum Retroviruses 2016[Apr]; 32 (4): 386-9 PMID26607272show ga
  • MicroRNAs (miRNAs) participate in host innate immunity against HIV-1 infection. We examined the impact of HIV-1 infection on viral restriction miRNAs in plasma of HIV-1?infected subjects. HIV-1?infected subjects had significantly lower plasma levels of HIV-1 restriction miRNAs (miRs-29a, ?29b, ?125b, ?223, ?198, and ?382) than control subjects. Further in vitro studies showed that HIV-1 infection of macrophages suppressed production of the extracellular miRs-29b, ?125b, and ?223. These data demonstrate the compelling evidence that HIV-1 infection impairs host innate immunity by inhibiting antiviral miRNAs, which provide a possible mechanism for HIV-1 persistence in the host.
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