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10.1002/bies.201500056 http://scihub22266oqcxt.onion/10.1002/bies.201500056 C4817226!4817226 !26866932     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26866932 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness |pdf=|usr=}}{{26866932 }} gab.com Text Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=26866932 #FOAvip Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep-wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non-transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24-hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems-level investigations implementing integrated multi-omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems. Twit Text FOAVip Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=26866932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26866932 #FOAvip English Wikipedia <ref>{{Cite pmid|26866932 }}</ref> Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness #MMPMID26866932 Ray S ; Reddy AB Bioessays 2016[Apr]; 38 (4 ): 394-405 PMID26866932 show ga Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep-wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non-transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24-hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems-level investigations implementing integrated multi-omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems. |*Signal Transduction [MESH] |Animals [MESH] |CLOCK Proteins/metabolism [MESH] |Circadian Clocks/*physiology [MESH] |Circadian Rhythm/*physiology [MESH] |Drosophila melanogaster/physiology [MESH] |Feedback, Physiological/*physiology [MESH] |Humans [MESH] |Metabolic Networks and Pathways/physiology [MESH] |Oxidation-Reduction [MESH] |Peroxiredoxins/metabolism [MESH] |Photoperiod [MESH] |Sirtuins/metabolism [MESH] |Sleep/*physiology [MESH] |Suprachiasmatic Nucleus/physiology [MESH] |Systems Biology [MESH]Cross-talk between circadian clocks, sleep-wake cycles, and metabolic (epmc).pdf DeepDyve Pubget Overpricing