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10.1126/science.aad5494 http://scihub22266oqcxt.onion/10.1126/science.aad5494 C4817221!4817221!26989246     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 351 (6279): 1293-6 Nephropedia Template TP {{tp|p=26989246|t=2016. The nutrient sensor OGT in PVN neurons regulates feeding |pdf=|usr=}}{{26989246}} gab.com Text The nutrient sensor OGT in PVN neurons regulates feeding JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26989246 #FOAvip Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to dietary factors and metabolic signals from peripheral organs. It is unclear how the brain interprets these signals. O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc and is regulated by nutrient access. Here, we show that acute deletion of OGT from ?CaMKII-positive neurons in adult mice caused obesity from overeating. The hyperphagia derived from the paraventricular nucleus (PVN) of the hypothalamus, where loss of OGT was associated with impaired satiety. These results identify O-GlcNAcylation in ?CaMKII neurons of the PVN as an important molecular mechanism that regulates feeding behavior. Twit Text FOAVip The nutrient sensor OGT in PVN neurons regulates feeding ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26989246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26989246 #FOAvip English Wikipedia <ref>{{Cite pmid|26989246}}</ref> The nutrient sensor OGT in PVN neurons regulates feeding #MMPMID26989246 Lagerlöf O; Slocomb JE; Hong I; Aponte Y; Blackshaw S; Hart GW; Huganir RL Science 2016[Mar]; 351 (6279): 1293-6 PMID26989246show ga Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to dietary factors and metabolic signals from peripheral organs. It is unclear how the brain interprets these signals. O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc and is regulated by nutrient access. Here, we show that acute deletion of OGT from ?CaMKII-positive neurons in adult mice caused obesity from overeating. The hyperphagia derived from the paraventricular nucleus (PVN) of the hypothalamus, where loss of OGT was associated with impaired satiety. These results identify O-GlcNAcylation in ?CaMKII neurons of the PVN as an important molecular mechanism that regulates feeding behavior. äThe nutrient sensor OGT in PVN neurons regulates feeding (epmc).pdf DeepDyve Pubget Overpricing