Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26175092
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26175092
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ups+J+Med+Sci
2015 ; 120
(4
): 233-40
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not
renal accumulation of hyaluronan
#MMPMID26175092
Stridh S
; Palm F
; Takahashi T
; Ikegami-Kawai M
; Hansell P
Ups J Med Sci
2015[]; 120
(4
): 233-40
PMID26175092
show ga
OBJECTIVES: Accumulation of extracellular matrix (ECM) components is an early
sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is
elevated in the renal interstitium during experimental diabetes. The mammalian
target of rapamycin (mTOR) pathway participates in the signaling of
hyperglycemia-induced ECM accumulation in the kidney, but this has not yet been
investigated for HA. We hypothesized that interstitial HA accumulation during
diabetes may involve mTOR activation. METHODS: Diabetic rats (6 weeks
post-streptozotocin (STZ)) were treated with rapamycin to inhibit mTOR or vehicle
for 2 additional weeks. Kidney function (glomerular filtration rate, renal blood
flow, urine output) and regional renal HA content were thereafter analyzed. The
ability of the animals to respond to desmopressin was also tested. RESULTS:
Diabetic animals displayed hyperglycemia, proteinuria, hyperfiltration, renal
hypertrophy, increased diuresis with reduced urine osmolality, and reduced weight
gain. Cortical and outer medullary HA was elevated in diabetic rats. Urine
hyaluronidase activity was almost doubled in diabetic rats compared with
controls. The ability to respond to desmopressin was absent in diabetic rats.
Renal blood flow and arterial blood pressure were unaffected by the diabetic
state. In diabetic rats treated with rapamycin the proteinuria was reduced by
32%, while all other parameters were unaffected. CONCLUSION: Regional renal
accumulation of the ECM component HA is not sensitive to mTOR inhibition by
rapamycin, while proteinuria is reduced in established STZ-induced diabetes.
Whether the diabetes-induced renal accumulation of HA occurs through different
pathways than other ECM components, or is irreversible after being established,
remains to be shown.
free
free
free
