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10.1210/en.2016-1003 http://scihub22266oqcxt.onion/10.1210/en.2016-1003 C4816734!4816734!26859334     free     free     free       Endocrinology 2016 ; 157 (4): 1328-40 Nephropedia Template TP {{tp|p=26859334|t=2016. Developmental Programming, a Pathway to Disease |pdf=|usr=}}{{26859334}} gab.com Text Developmental Programming, a Pathway to Disease JO: Endocrinology http://www.kidney.de/pget.php?&tw=1&pmid=26859334 #FOAvip Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions. Twit Text FOAVip Developmental Programming, a Pathway to Disease ????Endocrinology http://www.kidney.de/pget.php?&tw=1&pmid=26859334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26859334 #FOAvip English Wikipedia <ref>{{Cite pmid|26859334}}</ref> Developmental Programming, a Pathway to Disease #MMPMID26859334 Padmanabhan V; Cardoso RC; Puttabyatappa M Endocrinology 2016[Apr]; 157 (4): 1328-40 PMID26859334show ga Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions. äDevelopmental Programming, a Pathway to Disease (epmc).pdf DeepDyve Pubget Overpricing