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10.1016/j.ajpath.2015.11.006 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2015.11.006 C4816714!4816714 !26857506     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26857506 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma |pdf=|usr=}}{{26857506 }} gab.com Text Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26857506 #FOAvip Mild traumatic brain injury (mTBI) is an emerging risk for chronic behavioral, cognitive, and neurodegenerative conditions. Athletes absorb several hundred mTBIs each year; however, rodent models of repeat mTBI (rmTBI) are often limited to impacts in the single digits. Herein, we describe the effects of 30 rmTBIs, examining structural and pathological changes in mice up to 365 days after injury. We found that single mTBI causes a brief loss of consciousness and a transient reduction in dendritic spines, reflecting a loss of excitatory synapses. Single mTBI does not cause axonal injury, neuroinflammation, or cell death in the gray or white matter. Thirty rmTBIs with a 1-day interval between each mTBI do not cause dendritic spine loss; however, when the interinjury interval is increased to 7 days, dendritic spine loss is reinstated. Thirty rmTBIs cause white matter pathology characterized by positive silver and Fluoro-Jade B staining, and microglial proliferation and activation. This pathology continues to develop through 60 days, and is still apparent at 365 days, after injury. However, rmTBIs did not increase ?-amyloid levels or tau phosphorylation in the 3xTg-AD mouse model of Alzheimer disease. Our data reveal that single mTBI causes a transient loss of synapses, but that rmTBIs habituate to repetitive injury within a short time period. rmTBI causes the development of progressive white matter pathology that continues for months after the final impact. Twit Text FOAVip Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26857506 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26857506 #FOAvip English Wikipedia <ref>{{Cite pmid|26857506 }}</ref> Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma #MMPMID26857506 Winston CN ; Noël A ; Neustadtl A ; Parsadanian M ; Barton DJ ; Chellappa D ; Wilkins TE ; Alikhani AD ; Zapple DN ; Villapol S ; Planel E ; Burns MP Am J Pathol 2016[Mar]; 186 (3 ): 552-67 PMID26857506 show ga Mild traumatic brain injury (mTBI) is an emerging risk for chronic behavioral, cognitive, and neurodegenerative conditions. Athletes absorb several hundred mTBIs each year; however, rodent models of repeat mTBI (rmTBI) are often limited to impacts in the single digits. Herein, we describe the effects of 30 rmTBIs, examining structural and pathological changes in mice up to 365 days after injury. We found that single mTBI causes a brief loss of consciousness and a transient reduction in dendritic spines, reflecting a loss of excitatory synapses. Single mTBI does not cause axonal injury, neuroinflammation, or cell death in the gray or white matter. Thirty rmTBIs with a 1-day interval between each mTBI do not cause dendritic spine loss; however, when the interinjury interval is increased to 7 days, dendritic spine loss is reinstated. Thirty rmTBIs cause white matter pathology characterized by positive silver and Fluoro-Jade B staining, and microglial proliferation and activation. This pathology continues to develop through 60 days, and is still apparent at 365 days, after injury. However, rmTBIs did not increase ?-amyloid levels or tau phosphorylation in the 3xTg-AD mouse model of Alzheimer disease. Our data reveal that single mTBI causes a transient loss of synapses, but that rmTBIs habituate to repetitive injury within a short time period. rmTBI causes the development of progressive white matter pathology that continues for months after the final impact. |Amyloid/metabolism [MESH] |Animals [MESH] |Behavior, Animal [MESH] |Brain Concussion/pathology [MESH] |Brain Injuries/metabolism/*pathology [MESH] |Craniocerebral Trauma/metabolism/pathology [MESH] |Dendritic Spines/metabolism/*pathology [MESH] |Disease Models, Animal [MESH] |Fluoresceins [MESH] |Golgi Apparatus [MESH] |Humans [MESH] |Inflammation [MESH] |Male [MESH] |Maze Learning [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Recurrence [MESH] |Unconsciousness [MESH] |White Matter/metabolism/*pathology [MESH]Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse (epmc).pdf DeepDyve Pubget Overpricing