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10.1038/aps.2015.97 http://scihub22266oqcxt.onion/10.1038/aps.2015.97 C4816240!4816240 !26592519     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26592519 &cmd=llinks): Failed to open stream: HTTP request failed! 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The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels |pdf=|usr=}}{{26592519 }} gab.com Text The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=26592519 #FOAvip AIM: To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels (K(ATP)) by iptakalim in cultured rat mesenteric microvascular endothelial cells (MVECs). METHODS: Whole-cell KATP currents were recorded in MVECs using automated patch clamp devices. Nucleotides (ATP, ADP and UDP) were added to the internal perfusion system, whereas other drugs were added to the cell suspension on NPC-1 borosilicate glass chips. RESULTS: Application of iptakalim (10 and 100 ?mol/L) significantly increased the whole-cell K(ATP) currents, which were prevented by the specific K(ATP) blocker glibenclamide (1.0 ?mol/L). The opening of K(ATP) channels by iptakalim depended upon the intracellular concentrations of ATP or NDPs: iptakalim activated K(ATP) channels when the intracellular ATP or NDPs were at 100 or 1000 ?mol/L, and was ineffective when the non-hydrolysable ATP analogue ATP?S (1000 ?mol/L) was infused into the cells. In contrast, the K(ATP) opener pinacidil activated K(ATP) channels when the intracellular concentrations of ATP or NDPs ranged from 10 to 5000 ?mol/L, and even ATP?S (1000 ?mol/L) was infused into the cells. CONCLUSION: Iptakalim activates K(ATP) channels in the endothelial cells of resistance blood vessels with a low metabolic status, and this activation is dependent on both ATP hydrolysis and ATP ligands. Twit Text FOAVip The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=26592519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26592519 #FOAvip English Wikipedia <ref>{{Cite pmid|26592519 }}</ref> The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels #MMPMID26592519 Wang SY ; Cui WY ; Wang H Acta Pharmacol Sin 2015[Dec]; 36 (12 ): 1444-50 PMID26592519 show ga AIM: To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels (K(ATP)) by iptakalim in cultured rat mesenteric microvascular endothelial cells (MVECs). METHODS: Whole-cell KATP currents were recorded in MVECs using automated patch clamp devices. Nucleotides (ATP, ADP and UDP) were added to the internal perfusion system, whereas other drugs were added to the cell suspension on NPC-1 borosilicate glass chips. RESULTS: Application of iptakalim (10 and 100 ?mol/L) significantly increased the whole-cell K(ATP) currents, which were prevented by the specific K(ATP) blocker glibenclamide (1.0 ?mol/L). The opening of K(ATP) channels by iptakalim depended upon the intracellular concentrations of ATP or NDPs: iptakalim activated K(ATP) channels when the intracellular ATP or NDPs were at 100 or 1000 ?mol/L, and was ineffective when the non-hydrolysable ATP analogue ATP?S (1000 ?mol/L) was infused into the cells. In contrast, the K(ATP) opener pinacidil activated K(ATP) channels when the intracellular concentrations of ATP or NDPs ranged from 10 to 5000 ?mol/L, and even ATP?S (1000 ?mol/L) was infused into the cells. CONCLUSION: Iptakalim activates K(ATP) channels in the endothelial cells of resistance blood vessels with a low metabolic status, and this activation is dependent on both ATP hydrolysis and ATP ligands. |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Antihypertensive Agents/*pharmacology [MESH] |Cells, Cultured [MESH] |Endothelial Cells/*drug effects/metabolism [MESH] |KATP Channels/*metabolism [MESH] |Propylamines/*pharmacology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]The new antihypertensive drug iptakalim activates ATP-sensitive potass(epmc).pdf DeepDyve Pubget Overpricing