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2016 ; 8
(1
): 6418
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem,
Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and
Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious
Etiologies?
#MMPMID27103975
Chuh A
; Zawar V
; Sciallis GF
; Kempf W
; Lee A
Infect Dis Rep
2016[Mar]; 8
(1
): 6418
PMID27103975
show ga
Many clinical and laboratory-based studies have been reported for skin rashes
which may be due to viral infections, namely pityriasis rosea (PR),
Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral
laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome
(PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a
newly discovered paraviral rash. Novel tools are now available to investigate the
epidemiology of these rashes. To retrieve epidemiological data of these exanthema
and analyze whether such substantiates or refutes infectious etiologies. We
searched for articles published over the last 60 years and indexed by PubMed
database. We then analyzed them for universality, demography, concurrent
patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics,
and other clinical and geographical associations. Based on our criteria, we
selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and
EH respectively. Universality or multiple-continental reports are found for all
exanthema except EH. The ages of patients are compatible with infectious causes
for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all.
Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and
epidemics have been reported for GCS, EP, and EH. The current epidemiological
data supports, to a moderate extent, that PR, GCS, and APE could be caused by
infectious agents. Support for PPGSS is marginal. Epidemiological evidences for
infectious origins for EP and EH are inadequate. There might be growing
epidemiological evidence to substantiate or to refute our findings in the future.
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