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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.14814/phy2.12679 http://scihub22266oqcxt.onion/10.14814/phy2.12679 C4814882!4814882 !27009276     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27009276 &cmd=llinks): Failed to open stream: HTTP request failed! 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Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm |pdf=|usr=}}{{27009276 }} gab.com Text Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27009276 #FOAvip Although calcineurin (CN) is distributed in many cell types and functions in regulating cell functions, the precise roles ofCNremained in each type of the cells are not well understood yet. ACNinhibitor (CNI) has been used for steroid-resistant nephrotic syndrome. ACNIis assumed to ameliorate proteinuria by preventing the overproduction of T-cell cytokines. However, recent reports suggest thatCNIhas a direct effect on podocyte. It is accepted that a slit diaphragm (SD), a unique cell-cell junction of podocytes, is a critical barrier preventing a leak of plasma protein into urine. Therefore, we hypothesized thatCNIhas an effect on theSD In this study, we analyzed the expression ofCNin physiological and in the nephrotic model caused by the antibody against nephrin, a critical component of theSD We observed thatCNis expressed at theSDin normal rat and human kidney sections and has an interaction with nephrin. The staining ofCNat theSDwas reduced in the nephrotic model, whileCNactivity in glomeruli was increased. We also observed that the treatment with tacrolimus, aCNI, in this nephrotic model suppressed the redistribution ofCN, nephrin, and otherSDcomponents and ameliorated proteinuria. These observations suggested that the redistribution and the activation ofCNmay participate in the development of theSDinjury. Twit Text FOAVip Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27009276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27009276 #FOAvip English Wikipedia <ref>{{Cite pmid|27009276 }}</ref> Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm #MMPMID27009276 Wakamatsu A ; Fukusumi Y ; Hasegawa E ; Tomita M ; Watanabe T ; Narita I ; Kawachi H Physiol Rep 2016[Mar]; 4 (6 ): ä PMID27009276 show ga Although calcineurin (CN) is distributed in many cell types and functions in regulating cell functions, the precise roles ofCNremained in each type of the cells are not well understood yet. ACNinhibitor (CNI) has been used for steroid-resistant nephrotic syndrome. ACNIis assumed to ameliorate proteinuria by preventing the overproduction of T-cell cytokines. However, recent reports suggest thatCNIhas a direct effect on podocyte. It is accepted that a slit diaphragm (SD), a unique cell-cell junction of podocytes, is a critical barrier preventing a leak of plasma protein into urine. Therefore, we hypothesized thatCNIhas an effect on theSD In this study, we analyzed the expression ofCNin physiological and in the nephrotic model caused by the antibody against nephrin, a critical component of theSD We observed thatCNis expressed at theSDin normal rat and human kidney sections and has an interaction with nephrin. The staining ofCNat theSDwas reduced in the nephrotic model, whileCNactivity in glomeruli was increased. We also observed that the treatment with tacrolimus, aCNI, in this nephrotic model suppressed the redistribution ofCN, nephrin, and otherSDcomponents and ameliorated proteinuria. These observations suggested that the redistribution and the activation ofCNmay participate in the development of theSDinjury. |Animals [MESH] |Antibodies, Monoclonal [MESH] |Calcineurin Inhibitors/*pharmacology [MESH] |Calcineurin/*metabolism [MESH] |Cell Line [MESH] |Child [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Intercellular Junctions/*drug effects/enzymology/pathology [MESH] |Male [MESH] |Membrane Proteins/immunology/metabolism [MESH] |Mice [MESH] |Nephrotic Syndrome/chemically induced/congenital/*drug therapy/enzymology/pathology [MESH] |Podocytes/*drug effects/enzymology/pathology [MESH] |Protein Transport [MESH] |Proteinuria/chemically induced/*drug therapy/enzymology/pathology [MESH] |Rats, Wistar [MESH] |Tacrolimus/*pharmacology [MESH]Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor a(epmc).pdf DeepDyve Pubget Overpricing