Morphine Suppository versus Indomethacin Suppository in the Management of Renal
Colic: Randomized Clinical Trial
#MMPMID27073696
Zamanian F
; Jalili M
; Moradi-Lakeh M
; Kia M
; Aghili R
; Aghili SM
Pain Res Treat
2016[]; 2016
(?): 4981585
PMID27073696
show ga
Background. Renal colic is a medical emergency due to the rapid onset and
devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs
(NSAIDs) are both used as first-line choices in its management. Aim. This study
aimed to compare the efficacy and safety of opioids and NSAIDs in the management
of acute renal colic. Methods. One hundred and fifty-eight patients were divided
into two groups (n = 79) and received either 10?mg morphine or 100?mg
indomethacin suppositories. The severity of pain was measured using verbal
numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the
administration of analgesics. Drug side effects as well as patients' vital signs
were also recorded. Results. The mean decrease in the pain score during the first
20 minutes was significantly higher among those who received morphine
suppository. However, no significant difference was observed between the two
groups regarding the mean decrease in pain score during the first 40, 60, and 90
minutes after the admission. Prevalence of drug side effects or changes in the
vital signs was not significantly different between the two groups. Conclusions.
Morphine suppositories seem to be more efficient in achieving rapid pain relief
comparing to indomethacin.
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