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10.1021/acschemneuro.5b00176 http://scihub22266oqcxt.onion/10.1021/acschemneuro.5b00176 C4814290!4814290 !26212450     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26212450 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Chem+Neurosci 2015 ; 6 (9 ): 1503-8 Nephropedia Template TP {{tp|p=26212450 |t=2015. Real-Time Monitoring of Alzheimer s-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy |pdf=|usr=}}{{26212450 }} gab.com Text Real-Time Monitoring of Alzheimer s-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26212450 #FOAvip This work describes the use of fluorescence correlation spectroscopy (FCS) and a novel amyloid-binding fluorescent probe, ARCAM 1, to monitor the aggregation of the Alzheimer's disease-associated amyloid ?-peptide (A?). ARCAM 1 exhibits a large increase in fluorescence emission upon binding to A? assemblies, making it an excellent candidate for probe enhancement FCS (PE-FCS). ARCAM 1 binding does not change A? aggregation kinetics. It also exhibits greater dynamic range as a probe in reporting aggregate size by FCS in A?, when compared to thioflavin T (ThT) or an A? peptide modified with a fluorophore. Using fluorescent burst analysis (via PE-FCS) to follow aggregation of A?, we detected soluble aggregates at significantly earlier time points compared to typical bulk fluorescence measurements. Autocorrelation analysis revealed the size of these early A? assemblies. These results indicate that PE-FCS/ARCAM 1 based assays can detect and provide size characterization of small A? aggregation intermediates during the assembly process, which could enable monitoring and study of such aggregates that transiently accumulate in biofluids of patients with Alzheimer's and other neurodegenerative diseases. Twit Text FOAVip Real-Time Monitoring of Alzheimer s-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26212450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26212450 #FOAvip English Wikipedia <ref>{{Cite pmid|26212450 }}</ref> Real-Time Monitoring of Alzheimer s-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy #MMPMID26212450 Guan Y ; Cao KJ ; Cantlon A ; Elbel K ; Theodorakis EA ; Walsh DM ; Yang J ; Shah JV ACS Chem Neurosci 2015[Sep]; 6 (9 ): 1503-8 PMID26212450 show ga This work describes the use of fluorescence correlation spectroscopy (FCS) and a novel amyloid-binding fluorescent probe, ARCAM 1, to monitor the aggregation of the Alzheimer's disease-associated amyloid ?-peptide (A?). ARCAM 1 exhibits a large increase in fluorescence emission upon binding to A? assemblies, making it an excellent candidate for probe enhancement FCS (PE-FCS). ARCAM 1 binding does not change A? aggregation kinetics. It also exhibits greater dynamic range as a probe in reporting aggregate size by FCS in A?, when compared to thioflavin T (ThT) or an A? peptide modified with a fluorophore. Using fluorescent burst analysis (via PE-FCS) to follow aggregation of A?, we detected soluble aggregates at significantly earlier time points compared to typical bulk fluorescence measurements. Autocorrelation analysis revealed the size of these early A? assemblies. These results indicate that PE-FCS/ARCAM 1 based assays can detect and provide size characterization of small A? aggregation intermediates during the assembly process, which could enable monitoring and study of such aggregates that transiently accumulate in biofluids of patients with Alzheimer's and other neurodegenerative diseases. |Acrylamides/chemical synthesis/chemistry [MESH] |Alzheimer Disease/*metabolism [MESH] |Amyloid beta-Peptides/chemistry/*metabolism [MESH] |Benzothiazoles [MESH] |Fluorescent Dyes/chemical synthesis/chemistry [MESH] |Kinetics [MESH] |Molecular Structure [MESH] |Naphthalenes/chemical synthesis/chemistry [MESH] |Peptide Fragments/chemistry/*metabolism [MESH] |Protein Aggregates [MESH] |Solubility [MESH] |Spectrometry, Fluorescence/*methods [MESH]Real-Time Monitoring of Alzheimer s-Related Amyloid Aggregation via Pr(epmc).pdf DeepDyve Pubget Overpricing