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10.1681/ASN.2015040339 http://scihub22266oqcxt.onion/10.1681/ASN.2015040339 C4814192!4814192!26283674     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (4): 1091-101 Nephropedia Template TP {{tp|p=26283674|t=2016. Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1?Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism |pdf=|usr=}}{{26283674}} gab.com Text Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1 Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26283674 #FOAvip Secondary hyperparathyroidism is characterized by increased serum parathyroid hormone (PTH) level and parathyroid cell proliferation. However, the molecular pathways mediating the increased parathyroid cell proliferation remain undefined. Here, we found that the mTOR pathway was activated in the parathyroid of rats with secondary hyperparathyroidism induced by either chronic hypocalcemia or uremia, which was measured by increased phosphorylation of ribosomal protein S6 (rpS6), a downstream target of the mTOR pathway. This activation correlated with increased parathyroid cell proliferation. Inhibition of mTOR complex 1 by rapamycin decreased or prevented parathyroid cell proliferation in secondary hyperparathyroidism rats and in vitro in uremic rat parathyroid glands in organ culture. Knockin rpS6p?/? mice, in which rpS6 cannot be phosphorylated because of substitution of all five phosphorylatable serines with alanines, had impaired PTH secretion after experimental uremia- or folic acid?induced AKI. Uremic rpS6p?/? mice had no increase in parathyroid cell proliferation compared with a marked increase in uremic wild?type mice. These results underscore the importance of mTOR activation and rpS6 phosphorylation for the pathogenesis of secondary hyperparathyroidism and indicate that mTORC1 is a significant regulator of parathyroid cell proliferation through rpS6. Twit Text FOAVip Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1 Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26283674 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26283674 #FOAvip English Wikipedia <ref>{{Cite pmid|26283674}}</ref> Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1?Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism #MMPMID26283674 Volovelsky O; Cohen G; Kenig A; Wasserman G; Dreazen A; Meyuhas O; Silver J; Naveh-Many T J Am Soc Nephrol 2016[Apr]; 27 (4): 1091-101 PMID26283674show ga Secondary hyperparathyroidism is characterized by increased serum parathyroid hormone (PTH) level and parathyroid cell proliferation. However, the molecular pathways mediating the increased parathyroid cell proliferation remain undefined. Here, we found that the mTOR pathway was activated in the parathyroid of rats with secondary hyperparathyroidism induced by either chronic hypocalcemia or uremia, which was measured by increased phosphorylation of ribosomal protein S6 (rpS6), a downstream target of the mTOR pathway. This activation correlated with increased parathyroid cell proliferation. Inhibition of mTOR complex 1 by rapamycin decreased or prevented parathyroid cell proliferation in secondary hyperparathyroidism rats and in vitro in uremic rat parathyroid glands in organ culture. Knockin rpS6p?/? mice, in which rpS6 cannot be phosphorylated because of substitution of all five phosphorylatable serines with alanines, had impaired PTH secretion after experimental uremia- or folic acid?induced AKI. Uremic rpS6p?/? mice had no increase in parathyroid cell proliferation compared with a marked increase in uremic wild?type mice. These results underscore the importance of mTOR activation and rpS6 phosphorylation for the pathogenesis of secondary hyperparathyroidism and indicate that mTORC1 is a significant regulator of parathyroid cell proliferation through rpS6. äPhosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of R(epmc).pdf DeepDyve Pubget Overpricing