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10.1681/ASN.2014121214 http://scihub22266oqcxt.onion/10.1681/ASN.2014121214 C4814175!4814175!26315532     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (4): 1113-23 Nephropedia Template TP {{tp|p=26315532|t=2016. Double-Negative ?? T Cells Are Early Responders to AKI and Are Found in Human Kidney |pdf=|usr=}}{{26315532}} gab.com Text Double-Negative T Cells Are Early Responders to AKI and Are Found in Human Kidney JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26315532 #FOAvip Ischemia-reperfusion injury (IRI) is a major cause of AKI, and previous studies established important roles for conventional CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in AKI pathogenesis. We recently identified CD4?CD8? (double-negative; DN) T cells as an important subset of ?? T cell receptor?positive cells residing in mouse kidney. However, little is known about the pathophysiologic functions of kidney DN T cells. In this study, we phenotypically and functionally characterized murine kidney DN T cells in the steady state and in response to IRI. Unlike CD4+ and CD8+ T cells, DN T cells in the steady state expressed high levels of CD69, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inflammatory cytokines; spontaneously proliferated at a very high rate; and suppressed in vitro proliferation of activated CD4+ T cells. Within the first 3?24 hours after IRI, kidney DN T cells expanded significantly and upregulated expression of IL-10. In adoptive transfer experiments, DN T cells significantly protected recipients from AKI by an IL-10?dependent mechanism. DN T cells also made up a large fraction of the T cell compartment in human kidneys. Our results indicate that DN T cells are an important subset of the resident ??+ T cell population in the mammalian kidney and are early responders to AKI that have anti-inflammatory properties. Twit Text FOAVip Double-Negative T Cells Are Early Responders to AKI and Are Found in Human Kidney ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26315532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26315532 #FOAvip English Wikipedia <ref>{{Cite pmid|26315532}}</ref> Double-Negative ?? T Cells Are Early Responders to AKI and Are Found in Human Kidney #MMPMID26315532 Martina MN; Noel S; Saxena A; Bandapalle S; Majithia R; Jie C; Arend LJ; Allaf ME; Rabb H; Rahim A. Hamad A J Am Soc Nephrol 2016[Apr]; 27 (4): 1113-23 PMID26315532show ga Ischemia-reperfusion injury (IRI) is a major cause of AKI, and previous studies established important roles for conventional CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in AKI pathogenesis. We recently identified CD4?CD8? (double-negative; DN) T cells as an important subset of ?? T cell receptor?positive cells residing in mouse kidney. However, little is known about the pathophysiologic functions of kidney DN T cells. In this study, we phenotypically and functionally characterized murine kidney DN T cells in the steady state and in response to IRI. Unlike CD4+ and CD8+ T cells, DN T cells in the steady state expressed high levels of CD69, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inflammatory cytokines; spontaneously proliferated at a very high rate; and suppressed in vitro proliferation of activated CD4+ T cells. Within the first 3?24 hours after IRI, kidney DN T cells expanded significantly and upregulated expression of IL-10. In adoptive transfer experiments, DN T cells significantly protected recipients from AKI by an IL-10?dependent mechanism. DN T cells also made up a large fraction of the T cell compartment in human kidneys. Our results indicate that DN T cells are an important subset of the resident ??+ T cell population in the mammalian kidney and are early responders to AKI that have anti-inflammatory properties. äDouble-Negative ?? T Cells Are Early Responders to AKI and Are Found i(epmc).pdf DeepDyve Pubget Overpricing