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10.1002/eji.201545501 http://scihub22266oqcxt.onion/10.1002/eji.201545501 C4813659!4813659!26256265     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2015 ; 45 (11): 3034-44 Nephropedia Template TP {{tp|p=26256265|t=2015. Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33 |pdf=|usr=}}{{26256265}} gab.com Text Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33 JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26256265 #FOAvip Interleukin 33 (IL-33) released from damaged cells plays a central role in allergic inflammation by acting through its membrane-bound receptor, ST2 receptor (ST2L). IL-33 activity can be neutralized by the soluble spliced variant of ST2 (sST2) which has been associated with allergic inflammation but its source is not well defined. We investigated whether mast cells (MCs) are a significant source of sST2 following activation through Fc?RI or ST2. We find that antigen and IL-33 induce substantial production and release of sST2 from human and mouse MCs in culture and do so synergistically when added together or in combination with stem cell factor. Moreover, increases in circulating sST2 during anaphylaxis in mice were dependent on the presence of MCs. Human MCs activated via Fc?RI failed to generate IL-33 and IL-33 produced by mouse bone marrow-derived MCs was retained within the cells. Therefore, Fc?RI-mediated sST2 production is independent of MC-derived IL-33 acting in an autocrine manner. These results are consistent with the conclusion that both mouse and human MCs when activated are a significant inducible source of sST2 but not IL-33 and thus have the ability to modulate the biologic impact of IL-33 produced locally by other cell types during allergic inflammation. Twit Text FOAVip Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33 ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26256265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26256265 #FOAvip English Wikipedia <ref>{{Cite pmid|26256265}}</ref> Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33 #MMPMID26256265 Bandara G; Beaven MA; Olivera A; Gilfillan AM; Metcalfe DD Eur J Immunol 2015[Nov]; 45 (11): 3034-44 PMID26256265show ga Interleukin 33 (IL-33) released from damaged cells plays a central role in allergic inflammation by acting through its membrane-bound receptor, ST2 receptor (ST2L). IL-33 activity can be neutralized by the soluble spliced variant of ST2 (sST2) which has been associated with allergic inflammation but its source is not well defined. We investigated whether mast cells (MCs) are a significant source of sST2 following activation through Fc?RI or ST2. We find that antigen and IL-33 induce substantial production and release of sST2 from human and mouse MCs in culture and do so synergistically when added together or in combination with stem cell factor. Moreover, increases in circulating sST2 during anaphylaxis in mice were dependent on the presence of MCs. Human MCs activated via Fc?RI failed to generate IL-33 and IL-33 produced by mouse bone marrow-derived MCs was retained within the cells. Therefore, Fc?RI-mediated sST2 production is independent of MC-derived IL-33 acting in an autocrine manner. These results are consistent with the conclusion that both mouse and human MCs when activated are a significant inducible source of sST2 but not IL-33 and thus have the ability to modulate the biologic impact of IL-33 produced locally by other cell types during allergic inflammation. äActivated mast cells synthesize and release soluble ST2-a decoy recept(epmc).pdf DeepDyve Pubget Overpricing