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10.1242/jcs.181743 http://scihub22266oqcxt.onion/10.1242/jcs.181743 C4813320!4813320 !26801085     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26801085 &cmd=llinks): Failed to open stream: HTTP request failed! 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Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse |pdf=|usr=}}{{26801085 }} gab.com Text Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26801085 #FOAvip Monocyte-derived cells use an extracellular, acidic, lytic compartment (a lysosomal synapse) for initial degradation of large objects or species bound to the extracellular matrix. Akin to osteoclast degradation of bone, extracellular catabolism is used by macrophages to degrade aggregates of low density lipoprotein (LDL) similar to those encountered during atherogenesis. However, unlike osteoclast catabolism, the lysosomal synapse is a highly dynamic and intricate structure. In this study, we use high resolution three dimensional imaging to visualize compartments formed by macrophages to catabolize aggregated LDL. We show that these compartments are topologically complex, have a convoluted structure and contain sub-regions that are acidified. These sub-regions are characterized by a close apposition of the macrophage plasma membrane and aggregates of LDL that are still connected to the extracellular space. Compartment formation is dependent on local actin polymerization. However, once formed, compartments are able to maintain a pH gradient when actin is depolymerized. These observations explain how compartments are able to maintain a proton gradient while remaining outside the boundaries of the plasma membrane. Twit Text FOAVip Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26801085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26801085 #FOAvip English Wikipedia <ref>{{Cite pmid|26801085 }}</ref> Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse #MMPMID26801085 Singh RK ; Barbosa-Lorenzi VC ; Lund FW ; Grosheva I ; Maxfield FR ; Haka AS J Cell Sci 2016[Mar]; 129 (5 ): 1072-82 PMID26801085 show ga Monocyte-derived cells use an extracellular, acidic, lytic compartment (a lysosomal synapse) for initial degradation of large objects or species bound to the extracellular matrix. Akin to osteoclast degradation of bone, extracellular catabolism is used by macrophages to degrade aggregates of low density lipoprotein (LDL) similar to those encountered during atherogenesis. However, unlike osteoclast catabolism, the lysosomal synapse is a highly dynamic and intricate structure. In this study, we use high resolution three dimensional imaging to visualize compartments formed by macrophages to catabolize aggregated LDL. We show that these compartments are topologically complex, have a convoluted structure and contain sub-regions that are acidified. These sub-regions are characterized by a close apposition of the macrophage plasma membrane and aggregates of LDL that are still connected to the extracellular space. Compartment formation is dependent on local actin polymerization. However, once formed, compartments are able to maintain a pH gradient when actin is depolymerized. These observations explain how compartments are able to maintain a proton gradient while remaining outside the boundaries of the plasma membrane. |Actins/metabolism [MESH] |Animals [MESH] |Cell Membrane/metabolism/ultrastructure [MESH] |Cholesterol Esters/metabolism [MESH] |Hydrogen-Ion Concentration [MESH] |Hydrolysis [MESH] |Lipoproteins, LDL/*metabolism [MESH] |Lysosomes/*metabolism/ultrastructure [MESH] |Mice [MESH] |Protein Aggregates [MESH] |Protein Multimerization [MESH] |Proteolysis [MESH]Degradation of aggregated LDL occurs in complex extracellular sub-comp(epmc).pdf DeepDyve Pubget Overpricing