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10.1242/jcs.176792 http://scihub22266oqcxt.onion/10.1242/jcs.176792 C4813315!4813315 !26813789     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26813789 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2016 ; 129 (5 ): 994-1002 Nephropedia Template TP {{tp|p=26813789 |t=2016. Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology |pdf=|usr=}}{{26813789 }} gab.com Text Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26813789 #FOAvip Mitochondrial morphology is regulated by fusion and fission machinery. Impaired mitochondria dynamics cause various diseases, including Alzheimer's disease. Appoptosin (encoded by SLC25A38) is a mitochondrial carrier protein that is located in the mitochondrial inner membrane. Appoptosin overexpression causes overproduction of reactive oxygen species (ROS) and caspase-dependent apoptosis, whereas appoptosin downregulation abolishes ?-amyloid-induced mitochondrial fragmentation and neuronal death during Alzheimer's disease. Herein, we found that overexpression of appoptosin resulted in mitochondrial fragmentation in a manner independent of its carrier function, ROS production or caspase activation. Although appoptosin did not affect levels of mitochondrial outer-membrane fusion (MFN1 and MFN2), inner-membrane fusion (OPA1) and fission [DRP1 (also known as DNM1L) and FIS1] proteins, appoptosin interacted with MFN1 and MFN2, as well as with the mitochondrial ubiquitin ligase MITOL (also known as MARCH5) but not OPA1, FIS1 or DRP1. Appoptosin overexpression impaired the interaction between MFN1 and MFN2, and mitochondrial fusion. By contrast, co-expression of MFN1, MITOL and a dominant-negative form of DRP1, DRP1(K38A), partially rescued appoptosin-induced mitochondrial fragmentation and apoptosis, whereas co-expression of FIS1 aggravated appoptosin-induced apoptosis. Together, our results demonstrate that appoptosin can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. Twit Text FOAVip Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26813789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26813789 #FOAvip English Wikipedia <ref>{{Cite pmid|26813789 }}</ref> Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology #MMPMID26813789 Zhang C ; Shi Z ; Zhang L ; Zhou Z ; Zheng X ; Liu G ; Bu G ; Fraser PE ; Xu H ; Zhang YW J Cell Sci 2016[Mar]; 129 (5 ): 994-1002 PMID26813789 show ga Mitochondrial morphology is regulated by fusion and fission machinery. Impaired mitochondria dynamics cause various diseases, including Alzheimer's disease. Appoptosin (encoded by SLC25A38) is a mitochondrial carrier protein that is located in the mitochondrial inner membrane. Appoptosin overexpression causes overproduction of reactive oxygen species (ROS) and caspase-dependent apoptosis, whereas appoptosin downregulation abolishes ?-amyloid-induced mitochondrial fragmentation and neuronal death during Alzheimer's disease. Herein, we found that overexpression of appoptosin resulted in mitochondrial fragmentation in a manner independent of its carrier function, ROS production or caspase activation. Although appoptosin did not affect levels of mitochondrial outer-membrane fusion (MFN1 and MFN2), inner-membrane fusion (OPA1) and fission [DRP1 (also known as DNM1L) and FIS1] proteins, appoptosin interacted with MFN1 and MFN2, as well as with the mitochondrial ubiquitin ligase MITOL (also known as MARCH5) but not OPA1, FIS1 or DRP1. Appoptosin overexpression impaired the interaction between MFN1 and MFN2, and mitochondrial fusion. By contrast, co-expression of MFN1, MITOL and a dominant-negative form of DRP1, DRP1(K38A), partially rescued appoptosin-induced mitochondrial fragmentation and apoptosis, whereas co-expression of FIS1 aggravated appoptosin-induced apoptosis. Together, our results demonstrate that appoptosin can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. |Apoptosis [MESH] |Dynamins [MESH] |GTP Phosphohydrolases/*metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Membrane Fusion [MESH] |Membrane Proteins/*metabolism [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Mitochondria/metabolism/ultrastructure [MESH] |Mitochondrial Dynamics [MESH] |Mitochondrial Membrane Transport Proteins/*metabolism [MESH] |Mitochondrial Membranes/metabolism [MESH] |Mitochondrial Proteins/*metabolism [MESH] |Mitochondrial Size [MESH]Appoptosin interacts with mitochondrial outer-membrane fusion proteins(epmc).pdf DeepDyve Pubget Overpricing