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10.1242/jcs.183699 http://scihub22266oqcxt.onion/10.1242/jcs.183699 C4813297!4813297!26919980     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2016 ; 129 (6): 1093-100 Nephropedia Template TP {{tp|p=26919980|t=2016. The mechanical regulation of integrin?cadherin crosstalk organizes cells, signaling and forces |pdf=|usr=}}{{26919980}} gab.com Text The mechanical regulation of integrin cadherin crosstalk organizes cells, signaling and forces JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26919980 #FOAvip Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin?actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evidence shows that mechanically driven crosstalk between integrins and cadherins regulates the spatial distribution of these receptors, their signaling intermediates, the actin cytoskeleton and intracellular forces. This interplay between integrins and cadherins can control fibronectin matrix assembly and signaling, and a fine balance between traction forces at focal adhesions and intercellular tension at adherens junctions is crucial for directional collective cell migration. In this Commentary, we discuss two central ideas: (1) how the dynamic interplay between integrins and cadherins regulates the spatial organization of intracellular signals and the extracellular matrix, and (2) the emerging consensus that intracellular force is a central mechanism that dictates cell behavior, guides tissue development and ultimately drives physiology. Twit Text FOAVip The mechanical regulation of integrin cadherin crosstalk organizes cells, signaling and forces ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26919980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26919980 #FOAvip English Wikipedia <ref>{{Cite pmid|26919980}}</ref> The mechanical regulation of integrin?cadherin crosstalk organizes cells, signaling and forces #MMPMID26919980 Mui KL; Chen CS; Assoian RK J Cell Sci 2016[Mar]; 129 (6): 1093-100 PMID26919980show ga Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin?actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evidence shows that mechanically driven crosstalk between integrins and cadherins regulates the spatial distribution of these receptors, their signaling intermediates, the actin cytoskeleton and intracellular forces. This interplay between integrins and cadherins can control fibronectin matrix assembly and signaling, and a fine balance between traction forces at focal adhesions and intercellular tension at adherens junctions is crucial for directional collective cell migration. In this Commentary, we discuss two central ideas: (1) how the dynamic interplay between integrins and cadherins regulates the spatial organization of intracellular signals and the extracellular matrix, and (2) the emerging consensus that intracellular force is a central mechanism that dictates cell behavior, guides tissue development and ultimately drives physiology. äThe mechanical regulation of integrin?cadherin crosstalk organizes cel(epmc).pdf DeepDyve Pubget Overpricing