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2016 ; 17
(3
): 390
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a
Better Quality of Life after a First Ischemic Stroke
#MMPMID26999113
Alvarez-Sabín J
; Santamarina E
; Maisterra O
; Jacas C
; Molina C
; Quintana M
Int J Mol Sci
2016[Mar]; 17
(3
): 390
PMID26999113
show ga
Stroke, as the leading cause of physical disability and cognitive impairment, has
a very significant impact on patients' quality of life (QoL). The objective of
this study is to know the effect of citicoline treatment in Qol and cognitive
performance in the long-term in patients with a first ischemic stroke. This is an
open-label, randomized, parallel study of citicoline vs. usual treatment. All
subjects were selected 6 weeks after suffering a first ischemic stroke and
randomized into parallel arms. Neuropsychological evaluation was performed at 1
month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the
EuroQoL-5D questionnaire at 2 years. 163 patients were followed during 2 years.
The mean age was 67.5 years-old, and 50.9% were women. Age and absence of
citicoline treatment were independent predictors of both utility and poor quality
of life. Patients with cognitive impairment had a poorer QoL at 2 years (0.55 vs.
0.66 in utility, p = 0.015). Citicoline treatment improved significantly
cognitive status during follow-up (p = 0.005). In conclusion, treatment with
long-term citicoline is associated with a better QoL and improves cognitive
status 2 years after a first ischemic stroke.
|*Quality of Life
[MESH]
|Aged
[MESH]
|Brain Ischemia/*complications
[MESH]
|Cognitive Dysfunction/etiology/*prevention & control
[MESH]
|Cytidine Diphosphate Choline/*therapeutic use
[MESH]