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10.3892/etm.2016.3071 http://scihub22266oqcxt.onion/10.3892/etm.2016.3071 C4812482!4812482 !27073416     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27073416 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis |pdf=|usr=}}{{27073416 }} gab.com Text Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27073416 #FOAvip Sepsis-induced lymphocyte and dendritic cell apoptosis contributes to immunosuppression, resulting in an inability to eradicate the primary infection and a propensity to acquire secondary infections. However, the inhibition of apoptosis may produce unexpected and undesirable consequences. Another cellular process, autophagy, is also activated in immune cells. There is increasing evidence to suggest that autophagy confers a protective effect in sepsis. The protective mechanisms underlying this effect include limiting apoptotic cell death and maintaining cellular homeostasis. Therefore, understanding the regulation of immune cell autophagy and apoptosis may provide insight into novel therapeutic strategies. The present review examined potential novel therapeutic strategies aimed at restoring immune homeostasis by inducing autophagy. The restoration of balance between apoptosis and autophagy may be a novel approach for improving sepsis-induced immunosuppression and decreasing susceptibility to sepsis. Twit Text FOAVip Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27073416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27073416 #FOAvip English Wikipedia <ref>{{Cite pmid|27073416 }}</ref> Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis #MMPMID27073416 Zhang L ; Ai Y ; Tsung A Exp Ther Med 2016[Apr]; 11 (4 ): 1159-1167 PMID27073416 show ga Sepsis-induced lymphocyte and dendritic cell apoptosis contributes to immunosuppression, resulting in an inability to eradicate the primary infection and a propensity to acquire secondary infections. However, the inhibition of apoptosis may produce unexpected and undesirable consequences. Another cellular process, autophagy, is also activated in immune cells. There is increasing evidence to suggest that autophagy confers a protective effect in sepsis. The protective mechanisms underlying this effect include limiting apoptotic cell death and maintaining cellular homeostasis. Therefore, understanding the regulation of immune cell autophagy and apoptosis may provide insight into novel therapeutic strategies. The present review examined potential novel therapeutic strategies aimed at restoring immune homeostasis by inducing autophagy. The restoration of balance between apoptosis and autophagy may be a novel approach for improving sepsis-induced immunosuppression and decreasing susceptibility to sepsis. äClinical application: Restoration of immune homeostasis by autophagy a(epmc).pdf DeepDyve Pubget Overpricing