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10.1177/1740774515597698 http://scihub22266oqcxt.onion/10.1177/1740774515597698 C4812163!4812163!26374687     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Trials 2015 ; 12 (5): 476-84 Nephropedia Template TP {{tp|p=26374687|t=2015. Ethical responsibilities toward indirect and collateral participants in pragmatic clinical trials |pdf=|usr=}}{{26374687}} gab.com Text Ethical responsibilities toward indirect and collateral participants in pragmatic clinical trials JO: Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26374687 #FOAvip Pragmatic Clinical Trials (PCTs) are designed to inform decision makers about the benefits, burdens, and risks of health interventions in real-world settings. PCTs often use for research purposes data collected in the course of clinical practice. The distinctive features of PCTs demand fresh thinking about what is required to act properly toward people affected by their conduct, in ways that go beyond ensuring the protection of rights and welfare for ?human research subjects? under conventional research ethics regulations. To stimulate such work, we propose to distinguish among categories of research participants in PCTs as follows: Direct participants: (1) Individuals being directly intervened upon and/or (2) individuals from whom personal identifiable data are being collected for the purposes of the PCT. Indirect participants: Individuals who are (1) not identified as direct participants and (2) whose rights and welfare may be affected by the intervention through their routine exposure to the environment in which the intervention is being deployed. Collateral Participants: Patient groups and other stakeholder communities who may be otherwise affected by the occurrence and findings of the PCT. We illustrate these distinctions with case examples and discuss the distinctive responsibilities of researchers and PCT leadership toward each type of participant. We suggest that PCT investigators, Institutional Review Boards (IRBs), health systems leaders, and others engaged in the research enterprise work together to identify these participants. For indirect participants, risks and benefits to which they are exposed should be weighed to ensure that their rights and welfare are protected accordingly, and communication strategies should be considered to help them make well-informed decisions. Collateral participants could provide input on the design, planning and conduct of a PCT, and offer insights regarding the best way to communicate the trial?s results to their constituencies. Twit Text FOAVip Ethical responsibilities toward indirect and collateral participants in pragmatic clinical trials ????Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26374687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26374687 #FOAvip English Wikipedia <ref>{{Cite pmid|26374687}}</ref> Ethical responsibilities toward indirect and collateral participants in pragmatic clinical trials #MMPMID26374687 Smalley JB; Merritt MW; Al-Khatib SM; McCall D; Staman KL; Stepnowsky C Clin Trials 2015[Oct]; 12 (5): 476-84 PMID26374687show ga Pragmatic Clinical Trials (PCTs) are designed to inform decision makers about the benefits, burdens, and risks of health interventions in real-world settings. PCTs often use for research purposes data collected in the course of clinical practice. The distinctive features of PCTs demand fresh thinking about what is required to act properly toward people affected by their conduct, in ways that go beyond ensuring the protection of rights and welfare for ?human research subjects? under conventional research ethics regulations. To stimulate such work, we propose to distinguish among categories of research participants in PCTs as follows: Direct participants: (1) Individuals being directly intervened upon and/or (2) individuals from whom personal identifiable data are being collected for the purposes of the PCT. Indirect participants: Individuals who are (1) not identified as direct participants and (2) whose rights and welfare may be affected by the intervention through their routine exposure to the environment in which the intervention is being deployed. Collateral Participants: Patient groups and other stakeholder communities who may be otherwise affected by the occurrence and findings of the PCT. We illustrate these distinctions with case examples and discuss the distinctive responsibilities of researchers and PCT leadership toward each type of participant. We suggest that PCT investigators, Institutional Review Boards (IRBs), health systems leaders, and others engaged in the research enterprise work together to identify these participants. For indirect participants, risks and benefits to which they are exposed should be weighed to ensure that their rights and welfare are protected accordingly, and communication strategies should be considered to help them make well-informed decisions. Collateral participants could provide input on the design, planning and conduct of a PCT, and offer insights regarding the best way to communicate the trial?s results to their constituencies. äEthical responsibilities toward indirect and collateral participants i(epmc).pdf DeepDyve Pubget Overpricing