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2016 ; 4
(1
): 1-10
Nephropedia Template TP
gab.com Text
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English Wikipedia
Performance of a Multispectral Optoacoustic Tomography (MSOT) System equipped
with 2D vs 3D Handheld Probes for Potential Clinical Translation
#MMPMID27069872
Neuschmelting V
; Burton NC
; Lockau H
; Urich A
; Harmsen S
; Ntziachristos V
; Kircher MF
Photoacoustics
2016[Mar]; 4
(1
): 1-10
PMID27069872
show ga
A handheld approach to optoacoustic imaging is essential for the clinical
translation. The first 2- and 3-dimensional handheld multispectral optoacoustic
tomography (MSOT) probes featuring real-time unmixing have recently been
developed. Imaging performance of both probes was determined in vitro and in a
brain melanoma metastasis mouse model in vivo. T1-weighted MR images were
acquired for anatomical reference. The limit of detection of melanoma cells in
vitro was significantly lower using the 2D than the 3D probe. The signal decrease
was more profound in relation to depth with the 3D versus the 2D probe. Both
approaches were capable of imaging the melanoma tumors qualitatively at all time
points. Quantitatively, the 2D approach enabled closer anatomical resemblance of
the tumor compared to the 3D probe, particularly at depths beyond 3 mm. The 3D
probe was shown to be superior for rapid 3D imaging and, thus, holds promise for
more superficial target structures.