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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Microbiol
2016 ; 7
(ä): 402
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Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact
for the Infected Host
#MMPMID27064864
von Köckritz-Blickwede M
; Blodkamp S
; Nizet V
Front Microbiol
2016[]; 7
(ä): 402
PMID27064864
show ga
Since their discovery in 2004, neutrophil extracellular traps (NETs) have been
characterized as a fundamental host innate immune defense against various
pathogens. Released in response to infectious and pro-inflammatory stimuli, NETs
can immobilize invading pathogens within a fibrous matrix consisting of DNA,
histones, and antimicrobial peptides. Conversely, excessive or dysregulated NET
release may hold a variety of detrimental consequences for the host. A fine
balance between NET formation and elimination is necessary to sustain a
protective effect during infectious challenge. In recent years, a number of
microbial virulence factors have been shown to modulate formation of NETs,
thereby facilitating colonization or spread within the host. In this mini-review
we summarize the contemporary research on the interaction of bacterial exotoxins
with neutrophils that modulate NET production, focusing particular attention on
consequences for the host. Understanding host-pathogen dynamics in this
extracellular battlefield of innate immunity may provide novel therapeutic
approaches for infectious and inflammatory disorders.