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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Pharmacol+Sci 2016 ; 37 (4): 303-17 Nephropedia Template TP
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Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects #MMPMID26700098
Cai H; Dong L; Liu F
Trends Pharmacol Sci 2016[Apr]; 37 (4): 303-17 PMID26700098show ga
The increasing epidemic of obesity and its comorbidities has spurred research interest in adipose biology and its regulatory functions. Recent studies have revealed that the mechanistic target of rapamycin (mTOR) signaling pathway plays a critical role in the regulation of adipose tissue function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis/secretion. Given the extreme importance of mTOR signaling in controlling energy homeostasis, it is not unexpected that deregulated mTOR signaling is associated with obesity and related metabolic disorders. In this review, we highlight the current advances in the roles of the mTOR signaling pathway in adipose tissue. We also provide a more nuanced view of how the mTOR signaling pathway regulates adipose tissue biology and function. Finally, we describe approaches to modulate the activity and tissue specific function of mTOR that may pave the way towards counteracting obesity and related metabolic diseases.