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10.18632/oncotarget.6399 http://scihub22266oqcxt.onion/10.18632/oncotarget.6399 C4811477!4811477 !26621838     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26621838 &cmd=llinks): Failed to open stream: HTTP request failed! 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The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through ?v?3 integrin interaction |pdf=|usr=}}{{26621838 }} gab.com Text The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through v 3 integrin interaction JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26621838 #FOAvip Type XIX collagen is a minor collagen associated with basement membranes. It was isolated for the first time in a human cDNA library from rhabdomyosarcoma and belongs to the FACITs family (Fibril Associated Collagens with Interrupted Triple Helices). Previously, we demonstrated that the NC1 domain of collagen XIX (NC1(XIX)) exerts anti-tumor properties on melanoma cells by inhibiting their migration and invasion. In the present work, we identified for the first time the integrin ?v?3 as a receptor of NC1(XIX). Moreover, we demonstrated that NC1(XIX) inhibits the FAK/PI3K/Akt/mTOR pathway, by decreasing the phosphorylation and activity of the major proteins involved in this pathway. On the other hand, NC1(XIX) induced an increase of GSK3? activity by decreasing its degree of phosphorylation. Treatments targeting this central signaling pathway in the development of melanoma are promising and new molecules should be developed. NC1(XIX) seems to have the potential for the design of new anti-cancer drugs. Twit Text FOAVip The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through v 3 integrin interaction ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26621838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26621838 #FOAvip English Wikipedia <ref>{{Cite pmid|26621838 }}</ref> The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through ?v?3 integrin interaction #MMPMID26621838 Oudart JB ; Doué M ; Vautrin A ; Brassart B ; Sellier C ; Dupont-Deshorgue A ; Monboisse JC ; Maquart FX ; Brassart-Pasco S ; Ramont L Oncotarget 2016[Jan]; 7 (2 ): 1516-28 PMID26621838 show ga Type XIX collagen is a minor collagen associated with basement membranes. It was isolated for the first time in a human cDNA library from rhabdomyosarcoma and belongs to the FACITs family (Fibril Associated Collagens with Interrupted Triple Helices). Previously, we demonstrated that the NC1 domain of collagen XIX (NC1(XIX)) exerts anti-tumor properties on melanoma cells by inhibiting their migration and invasion. In the present work, we identified for the first time the integrin ?v?3 as a receptor of NC1(XIX). Moreover, we demonstrated that NC1(XIX) inhibits the FAK/PI3K/Akt/mTOR pathway, by decreasing the phosphorylation and activity of the major proteins involved in this pathway. On the other hand, NC1(XIX) induced an increase of GSK3? activity by decreasing its degree of phosphorylation. Treatments targeting this central signaling pathway in the development of melanoma are promising and new molecules should be developed. NC1(XIX) seems to have the potential for the design of new anti-cancer drugs. |*Signal Transduction/drug effects [MESH] |3-Phosphoinositide-Dependent Protein Kinases/metabolism [MESH] |Antineoplastic Agents/pharmacology [MESH] |Cell Line, Tumor [MESH] |Collagen/*metabolism/pharmacology [MESH] |Fibril-Associated Collagens/*metabolism/pharmacology [MESH] |Focal Adhesion Kinase 1/*metabolism [MESH] |Glycogen Synthase Kinase 3 beta/metabolism [MESH] |Humans [MESH] |Integrin alphaVbeta3/drug effects/*metabolism [MESH] |Melanoma/drug therapy/*enzymology/pathology [MESH] |Molecular Targeted Therapy [MESH] |Peptide Fragments/*metabolism/pharmacology [MESH] |Phosphatidylinositol 3-Kinase/*metabolism [MESH] |Phosphorylation [MESH] |Protein Domains [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |Skin Neoplasms/drug therapy/*enzymology/pathology [MESH]The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/m(epmc).pdf DeepDyve Pubget Overpricing