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10.18632/oncotarget.6363 http://scihub22266oqcxt.onion/10.18632/oncotarget.6363 C4811471!4811471 !26595526     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26595526 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (2 ): 1439-50 Nephropedia Template TP {{tp|p=26595526 |t=2016. ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism |pdf=|usr=}}{{26595526 }} gab.com Text ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26595526 #FOAvip Programmed cell death 4 (PDCD4) is a tumour suppressor implicated in cancer development and progression and was recently identified as a repressor of cap-independent translation of specific genes involved in the regulation of apoptosis. We show that the RNA-binding protein HuR binds to the PDCD4 3'UTR to protect it from miR-21-induced silencing. However, following H2O2 treatment, PDCD4 mRNA is degraded via miR-21 binding. Importantly, we identify HuR as a novel substrate of the ERK8 kinase pathway in response to H2O2 treatment. We show that phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4. Twit Text FOAVip ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26595526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26595526 #FOAvip English Wikipedia <ref>{{Cite pmid|26595526 }}</ref> ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism #MMPMID26595526 Liwak-Muir U ; Dobson CC ; Naing T ; Wylie Q ; Chehade L ; Baird SD ; Chakraborty PK ; Holcik M Oncotarget 2016[Jan]; 7 (2 ): 1439-50 PMID26595526 show ga Programmed cell death 4 (PDCD4) is a tumour suppressor implicated in cancer development and progression and was recently identified as a repressor of cap-independent translation of specific genes involved in the regulation of apoptosis. We show that the RNA-binding protein HuR binds to the PDCD4 3'UTR to protect it from miR-21-induced silencing. However, following H2O2 treatment, PDCD4 mRNA is degraded via miR-21 binding. Importantly, we identify HuR as a novel substrate of the ERK8 kinase pathway in response to H2O2 treatment. We show that phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4. |3' Untranslated Regions [MESH] |Apoptosis Regulatory Proteins/genetics/*metabolism [MESH] |Binding Sites [MESH] |ELAV-Like Protein 1/genetics/*metabolism [MESH] |Enzyme Activation [MESH] |Extracellular Signal-Regulated MAP Kinases/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Gene Silencing [MESH] |HeLa Cells [MESH] |Humans [MESH] |Hydrogen Peroxide/pharmacology [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Phosphorylation [MESH] |RNA Interference [MESH] |RNA Stability [MESH] |RNA, Messenger/genetics/metabolism [MESH] |RNA-Binding Proteins/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Time Factors [MESH] |Transfection [MESH]ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 thro(epmc).pdf DeepDyve Pubget Overpricing