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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2016 ; 7
(2
): 1107-19
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Altered expression of epithelial-to-mesenchymal transition proteins in
extraprostatic prostate cancer
#MMPMID26701730
Verrill C
; Cerundolo L
; Mckee C
; White M
; Kartsonaki C
; Fryer E
; Morris E
; Brewster S
; Ratnayaka I
; Marsden L
; Lilja H
; Muschel R
; Lu X
; Hamdy F
; Bryant RJ
Oncotarget
2016[Jan]; 7
(2
): 1107-19
PMID26701730
show ga
Epithelial to mesenchymal transition (EMT) of cancer cells involves loss of
epithelial polarity and adhesiveness, and gain of invasive and migratory
mesenchymal behaviours. EMT occurs in prostate cancer (PCa) but it is unknown
whether this is in specific areas of primary tumours. We examined whether any of
eleven EMT-related proteins have altered expression or subcellular localisation
within the extraprostatic extension component of locally advanced PCa compared
with other localisations, and whether similar changes may occur in in vitro
organotypic PCa cell cultures and in vivo PCa models. Expression profiles of
three proteins (E-cadherin, Snail, and ?-smooth muscle actin) were significantly
different in extraprostatic extension PCa compared with intra-prostatic tumour,
and 18/27 cases had an expression change of at least one of these three proteins.
Of the three significantly altered EMT proteins in pT3 samples, one showed
similar significantly altered expression patterns in in vitro organotypic culture
models, and two in in vivo Pten-/- model samples. These results suggest that
changes in EMT protein expression can be observed in the extraprostatic extension
component of locally invasive PCa. The biology of some of these changes in
protein expression may be studied in certain in vitro and in vivo PCa models.
|*Epithelial-Mesenchymal Transition
[MESH]
|Actins/*biosynthesis
[MESH]
|Aged
[MESH]
|Animals
[MESH]
|Cadherins/*biosynthesis
[MESH]
|Cell Line, Tumor
[MESH]
|Humans
[MESH]
|Immunohistochemistry
[MESH]
|Male
[MESH]
|Mice, Knockout
[MESH]
|Middle Aged
[MESH]
|Prostatic Neoplasms/*metabolism/pathology
[MESH]
|Snail Family Transcription Factors/*biosynthesis
[MESH]
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