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10.1016/j.molcel.2016.02.013 http://scihub22266oqcxt.onion/10.1016/j.molcel.2016.02.013 C4811377!4811377 !26942679     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26942679 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2016 ; 61 (5 ): 760-773 Nephropedia Template TP {{tp|p=26942679 |t=2016. A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence |pdf=|usr=}}{{26942679 }} gab.com Text A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26942679 #FOAvip MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNA-protein complex (microRNP) that lacks the microRNP repressor, GW182. Their mechanism in these conditions of decreased mTOR signaling, and therefore reduced canonical (cap-and-poly(A)-tail-mediated) translation, remains undiscovered. Our data reveal that mTOR inhibition in human THP1 cells enables microRNA-mediated activation. Activation requires shortened/no poly(A)-tail targets; polyadenylated mRNAs are partially activated upon PAIP2 overexpression, which interferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibition and canonical translation. Consistently, inhibition of PARN deadenylase prevents activation. P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is required for activation, and thereby for the oocyte immature state. P97 interacts with 3' UTR-binding FXR1a-associated microRNPs and with PARN, which binds mRNA 5' caps, forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions. Twit Text FOAVip A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26942679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26942679 #FOAvip English Wikipedia <ref>{{Cite pmid|26942679 }}</ref> A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence #MMPMID26942679 Bukhari SIA ; Truesdell SS ; Lee S ; Kollu S ; Classon A ; Boukhali M ; Jain E ; Mortensen RD ; Yanagiya A ; Sadreyev RI ; Haas W ; Vasudevan S Mol Cell 2016[Mar]; 61 (5 ): 760-773 PMID26942679 show ga MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNA-protein complex (microRNP) that lacks the microRNP repressor, GW182. Their mechanism in these conditions of decreased mTOR signaling, and therefore reduced canonical (cap-and-poly(A)-tail-mediated) translation, remains undiscovered. Our data reveal that mTOR inhibition in human THP1 cells enables microRNA-mediated activation. Activation requires shortened/no poly(A)-tail targets; polyadenylated mRNAs are partially activated upon PAIP2 overexpression, which interferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibition and canonical translation. Consistently, inhibition of PARN deadenylase prevents activation. P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is required for activation, and thereby for the oocyte immature state. P97 interacts with 3' UTR-binding FXR1a-associated microRNPs and with PARN, which binds mRNA 5' caps, forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions. |*Cellular Senescence [MESH] |*Protein Biosynthesis [MESH] |3' Untranslated Regions [MESH] |Animals [MESH] |Argonaute Proteins/genetics/metabolism [MESH] |Binding Sites [MESH] |Cell Line [MESH] |Eukaryotic Initiation Factor-4G/genetics/metabolism [MESH] |Exoribonucleases/genetics/metabolism [MESH] |Gene Expression Profiling/methods [MESH] |Humans [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Oocytes/*metabolism [MESH] |Proteomics/methods [MESH] |RNA Caps/genetics/metabolism [MESH] |RNA Interference [MESH] |RNA, Messenger/genetics/*metabolism [MESH] |RNA-Binding Proteins/genetics/*metabolism [MESH] |Repressor Proteins/genetics/metabolism [MESH] |Ribonucleoproteins/genetics/*metabolism [MESH] |Signal Transduction [MESH] |TOR Serine-Threonine Kinases/genetics/metabolism [MESH] |Transfection [MESH]A Specialized Mechanism of Translation Mediated by FXR1a-Associated Mi(epmc).pdf DeepDyve Pubget Overpricing