Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nsmb.2572 http://scihub22266oqcxt.onion/10.1038/nsmb.2572 C4811204!4811204!23644599     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2013 ; 20 (6): 735-9 Nephropedia Template TP {{tp|p=23644599|t=2013. Structural basis for the recruitment of the human CCR4?NOT deadenylase complex by Tristetraprolin |pdf=|usr=}}{{23644599}} gab.com Text Structural basis for the recruitment of the human CCR4 NOT deadenylase complex by Tristetraprolin JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=23644599 #FOAvip Tristetraprolin (TTP) is an RNA binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally represses gene expression by interacting with AU-rich elements (AREs) in 3?UTRs of target mRNAs and subsequently engenders their deadenylation and decay. TTP accomplishes these tasks, at least in part, by recruiting the multi subunit CCR4?NOT deadenylase complex to the mRNA. Here we identify an evolutionarily conserved C-terminal motif in human TTP that directly binds to a central domain of CNOT1, a core subunit of the CCR4?NOT complex. A high-resolution crystal structure of the TTP-CNOT1 complex was determined, providing the first structural insight into an ARE-binding protein bound to the CCR4?NOT complex. Mutations at the CNOT1-TTP interface impair TTP-mediated deadenylation, demonstrating the significance of this interaction in TTP-mediated gene silencing. Twit Text FOAVip Structural basis for the recruitment of the human CCR4 NOT deadenylase complex by Tristetraprolin ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=23644599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23644599 #FOAvip English Wikipedia <ref>{{Cite pmid|23644599}}</ref> Structural basis for the recruitment of the human CCR4?NOT deadenylase complex by Tristetraprolin #MMPMID23644599 Fabian MR; Frank F; Rouya C; Siddiqui N; Lai WS; Karetnikov A; Blackshear PJ; Nagar B; Sonenberg N Nat Struct Mol Biol 2013[Jun]; 20 (6): 735-9 PMID23644599show ga Tristetraprolin (TTP) is an RNA binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally represses gene expression by interacting with AU-rich elements (AREs) in 3?UTRs of target mRNAs and subsequently engenders their deadenylation and decay. TTP accomplishes these tasks, at least in part, by recruiting the multi subunit CCR4?NOT deadenylase complex to the mRNA. Here we identify an evolutionarily conserved C-terminal motif in human TTP that directly binds to a central domain of CNOT1, a core subunit of the CCR4?NOT complex. A high-resolution crystal structure of the TTP-CNOT1 complex was determined, providing the first structural insight into an ARE-binding protein bound to the CCR4?NOT complex. Mutations at the CNOT1-TTP interface impair TTP-mediated deadenylation, demonstrating the significance of this interaction in TTP-mediated gene silencing. äStructural basis for the recruitment of the human CCR4?NOT deadenylase(epmc).pdf DeepDyve Pubget Overpricing