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2016 ; 126
(4
): 1139-43
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gab.com Text
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Extracellular vesicles: masters of intercellular communication and potential
clinical interventions
#MMPMID27035805
Pitt JM
; Kroemer G
; Zitvogel L
J Clin Invest
2016[Apr]; 126
(4
): 1139-43
PMID27035805
show ga
Intercellular signaling via extracellular vesicles (EVs) is an underappreciated
modality of cell-cell crosstalk that enables cells to convey packages of complex
instructions to specific recipient cells. EVs transmit these instructions through
their cargoes of multiple proteins, nucleic acids, and specialized lipids, which
are derived from their cells of origin and allow for combinatorial effects upon
recipient cells. This Review series brings together the recent progress in our
understanding of EV signaling in physiological and pathophysiological conditions,
highlighting how certain EVs, particularly exosomes, can promote or regulate
infections, host immune responses, development, and various diseases - notably
cancer. Given the diverse nature of EVs and their abilities to profoundly
modulate host cells, this series puts particular emphasis on the clinical
applications of EVs as therapeutics and as diagnostic biomarkers.