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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Proc+Biol+Sci
2016 ; 283
(1826
): 20152861
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Host persistence or extinction from emerging infectious disease: insights from
white-nose syndrome in endemic and invading regions
#MMPMID26962138
Hoyt JR
; Langwig KE
; Sun K
; Lu G
; Parise KL
; Jiang T
; Frick WF
; Foster JT
; Feng J
; Kilpatrick AM
Proc Biol Sci
2016[Mar]; 283
(1826
): 20152861
PMID26962138
show ga
Predicting species' fates following the introduction of a novel pathogen is a
significant and growing problem in conservation. Comparing disease dynamics
between introduced and endemic regions can offer insight into which naive hosts
will persist or go extinct, with disease acting as a filter on host communities.
We examined four hypothesized mechanisms for host-pathogen persistence by
comparing host infection patterns and environmental reservoirs for
Pseudogymnoascus destructans (the causative agent of white-nose syndrome) in
Asia, an endemic region, and North America, where the pathogen has recently
invaded. Although colony sizes of bats and hibernacula temperatures were very
similar, both infection prevalence and fungal loads were much lower on bats and
in the environment in Asia than North America. These results indicate that
transmission intensity and pathogen growth are lower in Asia, likely due to
higher host resistance to pathogen growth in this endemic region, and not due to
host tolerance, lower transmission due to smaller populations, or lower
environmentally driven pathogen growth rate. Disease filtering also appears to be
favouring initially resistant species in North America. More broadly, determining
the mechanisms allowing species persistence in endemic regions can help identify
species at greater risk of extinction in introduced regions, and determine the
consequences for disease dynamics and host-pathogen coevolution.