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10.1093/eurheartj/ehu254 http://scihub22266oqcxt.onion/10.1093/eurheartj/ehu254 C4810804!4810804 !24980489     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24980489 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction |pdf=|usr=}}{{24980489 }} gab.com Text Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction JO: Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=24980489 #FOAvip AIM: Renal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal dysfunction was associated with measures of cardiovascular structure/function in patients with HFpEF. METHODS: We studied 217 participants from the PARAMOUNT study with HFpEF who had echocardiography and measures of kidney function. We evaluated the relationships between renal dysfunction [estimated glomerular filtration rate (eGFR) >30 and <60 mL/min/1.73 m(2) and/or albuminuria] and cardiovascular structure/function. RESULTS: The mean age of the study population was 71 years, 55% were women, 94% hypertensive, and 40% diabetic. Impairment of at least one parameter of kidney function was present in 62% of patients (16% only albuminuria, 23% only low eGFR, 23% both). Renal dysfunction was associated with abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) (adjusted P = 0.048), lower midwall fractional shortening (MWFS) (P = 0.009), and higher NT-proBNP (P = 0.006). Compared with patients without renal dysfunction, those with low eGFR and no albuminuria had a higher prevalence of abnormal LV geometry (P = 0.032) and lower MWFS (P < 0.01), as opposed to those with only albuminuria. Conversely, albuminuria alone was associated with greater LV dimensions (P < 0.05). Patients with combined renal impairment had mixed abnormalities (higher LV wall thicknesses, NT-proBNP; lower MWFS). CONCLUSION: Renal dysfunction, as determined by both eGFR and albuminuria, is highly prevalent in HFpEF, and associated with cardiac remodelling and subtle systolic dysfunction. The observed differences in cardiac structure/function between each type of renal damage suggest that both parameters of kidney function might play a distinct role in HFpEF. Twit Text FOAVip Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction ????Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=24980489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24980489 #FOAvip English Wikipedia <ref>{{Cite pmid|24980489 }}</ref> Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction #MMPMID24980489 Gori M ; Senni M ; Gupta DK ; Charytan DM ; Kraigher-Krainer E ; Pieske B ; Claggett B ; Shah AM ; Santos AB ; Zile MR ; Voors AA ; McMurray JJ ; Packer M ; Bransford T ; Lefkowitz M ; Solomon SD Eur Heart J 2014[Dec]; 35 (48 ): 3442-51 PMID24980489 show ga AIM: Renal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal dysfunction was associated with measures of cardiovascular structure/function in patients with HFpEF. METHODS: We studied 217 participants from the PARAMOUNT study with HFpEF who had echocardiography and measures of kidney function. We evaluated the relationships between renal dysfunction [estimated glomerular filtration rate (eGFR) >30 and <60 mL/min/1.73 m(2) and/or albuminuria] and cardiovascular structure/function. RESULTS: The mean age of the study population was 71 years, 55% were women, 94% hypertensive, and 40% diabetic. Impairment of at least one parameter of kidney function was present in 62% of patients (16% only albuminuria, 23% only low eGFR, 23% both). Renal dysfunction was associated with abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) (adjusted P = 0.048), lower midwall fractional shortening (MWFS) (P = 0.009), and higher NT-proBNP (P = 0.006). Compared with patients without renal dysfunction, those with low eGFR and no albuminuria had a higher prevalence of abnormal LV geometry (P = 0.032) and lower MWFS (P < 0.01), as opposed to those with only albuminuria. Conversely, albuminuria alone was associated with greater LV dimensions (P < 0.05). Patients with combined renal impairment had mixed abnormalities (higher LV wall thicknesses, NT-proBNP; lower MWFS). CONCLUSION: Renal dysfunction, as determined by both eGFR and albuminuria, is highly prevalent in HFpEF, and associated with cardiac remodelling and subtle systolic dysfunction. The observed differences in cardiac structure/function between each type of renal damage suggest that both parameters of kidney function might play a distinct role in HFpEF. |Aged [MESH] |Albuminuria/pathology/physiopathology [MESH] |Cardio-Renal Syndrome/pathology/*physiopathology [MESH] |Creatinine/urine [MESH] |Echocardiography [MESH] |Female [MESH] |Glomerular Filtration Rate/physiology [MESH] |Humans [MESH] |Hypertrophy, Left Ventricular/pathology/physiopathology [MESH] |Male [MESH] |Prospective Studies [MESH]Association between renal function and cardiovascular structure and fu(epmc).pdf DeepDyve Pubget Overpricing