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10.1083/jcb.201506132

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suck abstract from ncbi


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pmid27002170      J+Cell+Biol 2016 ; 212 (7): 861-75
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  • Smoothened determines ?-arrestin?mediated removal of the G protein?coupled receptor Gpr161 from the primary cilium #MMPMID27002170
  • Pal K; Hwang Sh; Somatilaka B; Badgandi H; Jackson PK; DeFea K; Mukhopadhyay S
  • J Cell Biol 2016[Mar]; 212 (7): 861-75 PMID27002170show ga
  • Pal et al. describe a two-step process determining removal of the cilia-localized GPCR, Gpr161, upon sonic hedgehog signaling. First, ?-arrestins are recruited by the signaling-competent receptor in a smoothened-dependent manner. Second, clathrin-mediated endocytosis outside of the ciliary compartment coordinates removal.
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