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10.3389/fimmu.2016.00114

http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00114
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suck abstract from ncbi


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pmid27066006      Front+Immunol 2016 ; 7 (ä): ä
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  • Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function #MMPMID27066006
  • Kouidhi S; Noman MZ; Kieda C; Elgaaied AB; Chouaib S
  • Front Immunol 2016[]; 7 (ä): ä PMID27066006show ga
  • It is well recognized that the immune system and metabolism are highly integrated. In this context, multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. This review will discuss different potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. We will also provide a general framework for understanding how tumor microenvironmental metabolism, associated with hypoxic stress, interferes with T-cell priming and expansion. How T-cell metabolism drives T-cell-mediated immunity and how the manipulation of metabolic programing for therapeutic purposes will be also discussed.
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