Cdc42 and cellular polarity: Emerging roles at the Golgi #MMPMID26704441
Farhan H; Hsu VW
Trends Cell Biol 2016[Apr]; 26 (4): 241-8 PMID26704441show ga
Cdc42 belongs to the Rho family of small GTPases and plays key roles in cellular events of polarity. This role of Cdc42 has typically been attributed to its function at the plasma membrane. However, Cdc42 also exists at the Golgi complex. In this review, we summarize major insights that have been gathered in studying the Golgi-pool of Cdc42 and propose that Golgi-localized Cdc42 enables the cell to diversify the function of Cdc42, which in some cases represent new roles, and in other cases act to complement the established roles of Cdc42 at the plasma membrane. Studies on how Cdc42 acts at the Golgi also suggest key questions to address in the future.